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Table 3 Urinary pharmacokinetic parameters

From: Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series

Parameter

N

ADR

 

Dose A

Dose B

Ratio (B/A)

Dose C

Dose D

Ratio (D/C)

Total urine volume (12 h, mL)

3132

3090

0.99

2488

267

0.11

Methadone

      

C (ng/mL)

52.6

54.6

1.0

88.6

1168

13.2

Total mass (μg)

165

169

1.0

220

312

1.4

Masstotal/AUC0-12 h (L/hour)

0.84

0.88

1.0

1.14

0.26

0.23

EDDP

      

C (ng/mL)

12.7

8.97

0.71

25.5

424

16.6

Total mass (μg)

39.7

27.7

0.70

63.4

113

1.8

C(methadone)/C(EDDP)

4.14

6.09

1.47

3.47

2.75

0.79

EMDP

      

C (ng/mL)

0.044

0.036

0.82

0.019

0.23

12.1

Total mass (μg)

0.14

0.11

0.79

0.047

0.062

1.3

  1. AUC = area under the plasma concentration time curve; AUC0-12 h = AUC from time 0 to 12 hours; ADR = our patient who experienced methadone overexposure; C = concentration; EDDP = 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (primary metabolite of methadone); EMDP = 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (secondary metabolite of methadone); N = our unaffected patient.
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Journal of Medical Case Reports

ISSN: 1752-1947