Figure 1
From: Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series
Course of the adverse event over the first five hours after the dose of methadone. The white arrows under the name of each medication indicate their times of administration. Shaded boxes on lines following specific symptoms indicate the times and duration of those symptoms. Double-headed arrow: during this time, vital signs worsened. The lowest blood pressure recorded was 110/86, respiratory rates as low as five breaths/minute occurred, and pulse oximetry documented oxygen saturation as low as 75%.