Table 1 mRNA expression of genes involved in adipogenesis, metabolism, inflammation and mitochondrial function in adipose tissue from our patient with APL
Healthy controls | APL | Change | |
|---|---|---|---|
Adipogenesis (+) | |||
PPARγ mRNA | 2.78 (1.81–3.74) × 10-5 | 1.35 × 10-5 | ↓ |
C/EBPα mRNA | 1.55 (0.93–2.03) × 10-4 | 1.66 × 10-4 | = |
Adipogenesis (-) | |||
pRb mRNA | 7.52 (3.47–11.57) × 10-6 | 3.84 × 10-6 | = |
Pref-1 mRNA | 0.44 (0.03–0.84) × 10-9 | 0.04 × 10-9 | = |
Adipokines | |||
Leptin mRNA | 0.73 (0.41–1.02) × 10-4 | 0.85 × 10-4 | = |
Adiponectin mRNA | 1.05 (0.69–1.39) × 10-3 | 0.49 × 10-3 | ↓ |
Metabolism | |||
GLUT4 mRNA | 0.96 (0.43–1.47) × 10-5 | 0.13 × 10-6 | ↓ |
LPL mRNA | 2.88 (2.15–3.47) × 10-4 | 0.73 × 10-4 | ↓ |
Inflammation | |||
TNFα mRNA | 5.18 (2.74–7.63) × 10-7 | 4.56 × 10-7 | = |
MCP-1 mRNA | 0.24 (0.07–0.40) × 10-5 | 0.19 × 10-5 | = |
β2-microglobulin mRNA | 2.85 (2.06–3.49) × 10-4 | 3.12 × 10-4 | = |
CD68 mRNA | 0.75 (0.26–1.24) × 10-4 | 1.01 × 10-4 | = |
Complement system | |||
Component 3 mRNA | 1.99 (0.91–3.07) × 10-4 | 2.08 × 10-4 | = |
OXPHOS | |||
COII mRNA | 1.17 (0.74–1.51) × 10-2 | 0.35 × 10-2 | ↓ |
COIV mRNA | 4.24 (3.42–4.81) × 10-5 | 1.55 × 10-5 | ↓ |
ATPsynthase F0-6 mRNA | 6.77 (4.85–8.69) × 10-5 | 2.10 × 10-5 | ↓ |
UCPs | |||
UCP2 mRNA | 4.05 (2.74–5.77) × 10-5 | 5.72 × 10-5 | = |
UCP3 mRNA | 4.13 (1.67–6.50) × 10-7 | 2.56 × 10-7 | = |
Mitochondriogenesis regulators | |||
PGC-1α mRNA | 1.12 (0.71–1.51) × 10-6 | 0.82 × 10-6 | = |
NRF-1 mRNA | 4.06 (2.96–5.26) × 10-6 | 3.37 × 10-6 | = |