Figure 3

Hematoxylin and eosin, periodic acid Schiff, Grocott and Elastica von Gieson stained sections of sampled lung tissue. (a, b) Diffuse alveolar damage with denuded edematous alveolar septa with thick hyaline membranes and intra-alveolar hemorrhage. (c) Aspergilloma composed of radiating regularly branched fungal hyphae (periodic acid Schiff stain, insert: high magnification Grocott stain). (d, e, f) Lung parenchyma with severely distorted architecture consisting of established fibrosis with sharply angulated and cystically dilated bronchioli with inspissated secretions. In the interstitium a patchy lympho-histiocytic infiltrate is present (f). Bronchiolar smooth muscle hypertrophy (e) and squamous metaplasia (f) is seen.