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Table 1 Literature review of primary pancreatic lymphoma: patients' characteristics, pathologic types, treatment and outcome

From: A role for surgery in primary pancreatic B-cell lymphoma: a case report

First author Year Number (n) Pathology Operation Chemotherapy Radiotherapy Outcome Response
Feather 1951 1 DLBCL Total Pancreatectomy None None 16 months – NED CR
Acherman 1976 3 DLBCL None CHOP Yes 12 months – NED CR
Boddie 1980 2 DLBCL      
Freed 1983 1 NR Distal Pancreatectomy None None 12 months – NED CR
Teefy 1986 2 DLBCL (1) FLCL (1) None Yes Yes 12 months – Death PR
Hart 1987 14 Histiocytic (9) Poorly diff lymphocytic (2) Well diff lymphocytic (1) T-cell (1) Undifferentiated(1) Distal Pancreatectomy (1) CHOP (14) 1 of 14 NR (1 with resection) Death (7) at 3 to 108 months) NR
Webb 1988 9 DLBCL (6) Follicular mixed (2) Small cleaved (1) Distal Pancreatectomy (1) MACOP-B (8) CAMEL (1) None 95 months-NED (1) 21 months-NED (8) CR
Mansour 1989 12 NR Distal Pancreatectomy(1) CHOP (11) 5 of 9 Death (5) in 2 to 11 months, Recurrence (2) in 3 and 48 months PR
Cappell 1989 1 DLBCL      
Tuchek 1993 7 NR None CHOP (1) CVP (1) CAMEL (1) NR Death (4) Alive (3) at 60, 72, 96 months CR
Borrowdale 1994 1 NR Whipple Yes None Death in 12 months CR
Behrns 1994 12 DLBCL (7) Small cleaved (2) Mixed (3) Whipple (1) Bypass (4) CHOP (4) 4 of 12 Death in 38 months at most PR
Fidias 1995 3 DLBCL None CHOP None Death (1) Recurrence (1) NED in 36 months(1) CR (2) PR (1)
Tanaka 1996 1 DLBCL (1) Whipple CHOP NR NED in 36 months CR
Ezzat 1996 5 DLBCL (5) Whipple (1) CHOP (4) CHOP-Ble (1) NR NED in 21 to 84 months (4) PR
Rumstadt 1997 2 DLBCL (2) Whipple (2) CHOP (1) None NED in 29 months CR
Bouvet 1997 11 DLBCL (10) Mixed follicular (1) Whipple (1) Distal Pancreaticoduo-denectomy (2) CHOP-Bleo 7of 11 Death (3) Recurrence (2) NED (6) CR
James 1997 2 DLBCL (1) None CHOP (1) PACEBO + CHOP (1) 1 of 2 NED in 24 months PR
Koniaris 2000 8 DLBCL (7) Nixed follicular (1) Whipple (3) CHOP (6) MACOP-B None Death (2) NED (3, resection) CR
Islam 2001 1 DLBCL Bypass, biopsy CHOP None NED in 18 months CR
Nishimura 2001 19 DLBCL (15) T-cell (4) Pancreatectomy(10) CHOP (5) Mitomycin Tegafur (1) Unspecified chemo (1) NR 1-year actuarial survival B-cell: 51.9% T-cell: 0% PR
Boni 2002 1 DLBCL (1) Laparoscopy-biopsy Chemo (1) None NED in 9 months CR
Hauksson 2002 1 DLBCL PTC stenting biopsy Chemo NR NR NR
Volmar 2004 14 DLBCL (6) follicular (4) Suggestive of lymphoma (3) B lymphoma (1) No Yes NR Death (3) Alive (11) in a mean 11.8- month followup 2 PR 11 CR
Nayer 200410 8 DLBCL (4) High-grade B-cell (1) Low grade B (2) Suspicious (1) None Chemo (4) Chemo and auto SCT (2) Nr (2) 3 of 8 6 alive at 2 to 6 months PR
Pezzilli 2004 1 T-cell lymphoma None Chemo (1) None Death (1) NR
Arcari 2005 5 DLBCL (3) Lymphoplasmacytic (2) Pancreatectomy (2) CVP/CHOP(3) CHOP(1) CVP(1) 2 of 5 Death (3) Alive 2, (1, resection) PR
Grimison 2005 4 DLBCL (3) Follicular (1) None CHOP(2) Rituximab-CHOP(1) CVP(1) 4 Death 132 months Alive 3 at 15, 25, 64 months PR
Ji 2005 1 DLBCL (1) Whipple (1) NR NR NR NR
Savopoulos 2005 1 ALCL (1) Biopsy None None Died 2nd postoperative day -
Kang 2006 1 Non-Hodgkin's lymphoma Biopsy NR NR NR NR
Lin 2006 6 DLBCL (6) Whipple (2) Pancreatectomy (1) Biliary decompression (1) Chemo (6) γ-radiotherapy (1) Death (3) at 2, 37, 49 months NED in 21 months (1) PR
Battula 2006 1 DLBCL (1) Whipple (1) CHOP (1) NR NR NR
Liakakos 2007 1 DLBCL (1) Whipple (1) Cyclophosphamide Novantrone Vincristine Prednisone No Alive (2 years) PR
  1. DLBCL, diffuse large B-cell lymphoma; FLCL, follicular large cell lymphoma; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisolone; PACEBO, prednisolone, hydroxydaunorubicine, cyclophosphamide, etoposide, bleomycin, vincristine; CAMEL, cyclophosphamide, adriamycin, vincristine, prednisone; CVP, cyclophosphamide, vincristine, prednisone; SCT, stem cell transplantation; NED, no evidence of disease; NR, not reported; CR, complete response; PR, partial response