Table 1 Literature review of primary pancreatic lymphoma: patients' characteristics, pathologic types, treatment and outcome

Feather

1951

1

DLBCL

Total Pancreatectomy

None

None

16 months – NED

CR

Acherman

1976

3

DLBCL

None

CHOP

Yes

12 months – NED

CR

Boddie

1980

2

DLBCL

Freed

1983

1

NR

Distal Pancreatectomy

None

None

12 months – NED

CR

Teefy

1986

2

DLBCL (1) FLCL (1)

None

Yes

Yes

12 months – Death

PR

Hart

1987

14

Histiocytic (9) Poorly diff lymphocytic (2) Well diff lymphocytic (1) T-cell (1) Undifferentiated(1)

Distal Pancreatectomy (1)

CHOP (14)

1 of 14

NR (1 with resection) Death (7) at 3 to 108 months)

NR

Webb

1988

9

DLBCL (6) Follicular mixed (2) Small cleaved (1)

Distal Pancreatectomy (1)

MACOP-B (8) CAMEL (1)

None

95 months-NED (1) 21 months-NED (8)

CR

Mansour

1989

12

NR

Distal Pancreatectomy(1)

CHOP (11)

5 of 9

Death (5) in 2 to 11 months, Recurrence (2) in 3 and 48 months

PR

Cappell

1989

1

DLBCL

Tuchek

1993

7

NR

None

CHOP (1) CVP (1) CAMEL (1)

NR

Death (4) Alive (3) at 60, 72, 96 months

CR

Borrowdale

1994

1

NR

Whipple

Yes

None

Death in 12 months

CR

Behrns

1994

12

DLBCL (7) Small cleaved (2) Mixed (3)

Whipple (1) Bypass (4)

CHOP (4)

4 of 12

Death in 38 months at most

PR

Fidias

1995

3

DLBCL

None

CHOP

None

Death (1) Recurrence (1) NED in 36 months(1)

CR (2) PR (1)

Tanaka

1996

1

DLBCL (1)

Whipple

CHOP

NR

NED in 36 months

CR

Ezzat

1996

5

DLBCL (5)

Whipple (1)

CHOP (4) CHOP-Ble (1)

NR

NED in 21 to 84 months (4)

PR

Rumstadt

1997

2

DLBCL (2)

Whipple (2)

CHOP (1)

None

NED in 29 months

CR

Bouvet

1997

11

DLBCL (10) Mixed follicular (1)

Whipple (1) Distal Pancreaticoduo-denectomy (2)

CHOP-Bleo

7of 11

Death (3) Recurrence (2) NED (6)

CR

James

1997

2

DLBCL (1)

None

CHOP (1) PACEBO + CHOP (1)

1 of 2

NED in 24 months

PR

Koniaris

2000

8

DLBCL (7) Nixed follicular (1)

Whipple (3)

CHOP (6) MACOP-B

None

Death (2) NED (3, resection)

CR

Islam

2001

1

DLBCL

Bypass, biopsy

CHOP

None

NED in 18 months

CR

Nishimura

2001

19

DLBCL (15) T-cell (4)

Pancreatectomy(10)

CHOP (5) Mitomycin Tegafur (1) Unspecified chemo (1)

NR

1-year actuarial survival B-cell: 51.9% T-cell: 0%

PR

Boni

2002

1

DLBCL (1)

Laparoscopy-biopsy

Chemo (1)

None

NED in 9 months

CR

Hauksson

2002

1

DLBCL

PTC stenting biopsy

Chemo

NR

NR

NR

Volmar

2004

14

DLBCL (6) follicular (4) Suggestive of lymphoma (3) B lymphoma (1)

No

Yes

NR

Death (3) Alive (11) in a mean 11.8- month followup

2 PR 11 CR

Nayer

2004¹⁰

8

DLBCL (4) High-grade B-cell (1) Low grade B (2) Suspicious (1)

None

Chemo (4) Chemo and auto SCT (2) Nr (2)

3 of 8

6 alive at 2 to 6 months

PR

Pezzilli

2004

1

T-cell lymphoma

None

Chemo (1)

None

Death (1)

NR

Arcari

2005

5

DLBCL (3) Lymphoplasmacytic (2)

Pancreatectomy (2)

CVP/CHOP(3) CHOP(1) CVP(1)

2 of 5

Death (3) Alive 2, (1, resection)

PR

Grimison

2005

4

DLBCL (3) Follicular (1)

None

CHOP(2) Rituximab-CHOP(1) CVP(1)

4

Death 132 months Alive 3 at 15, 25, 64 months

PR

Ji

2005

1

DLBCL (1)

Whipple (1)

NR

NR

NR

NR

Savopoulos

2005

1

ALCL (1)

Biopsy

None

None

Died 2^nd postoperative day

-

Kang

2006

1

Non-Hodgkin's lymphoma

Biopsy

NR

NR

NR

NR

Lin

2006

6

DLBCL (6)

Whipple (2) Pancreatectomy (1) Biliary decompression (1)

Chemo (6)

γ-radiotherapy (1)

Death (3) at 2, 37, 49 months NED in 21 months (1)

PR

Battula

2006

1

DLBCL (1)

Whipple (1)

CHOP (1)

NR

NR

NR

Liakakos

2007

1

DLBCL (1)

Whipple (1)

Cyclophosphamide Novantrone Vincristine Prednisone

No

Alive (2 years)

PR