Skip to main content

Table 1 Published reports of bupropion hepatotoxicity

From: A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: Case report

Author (yr) Dose Duration of use (Days) Peak ALT (IU/L) Peak bilirubin (mg/dl) Outcome
Oslin ('93) 300 mg QD × 21 days, then 400 mg QD 54 5.4 × ULN Not reported Resolution
Hu ('00) 200 mg QD 42 6660 3.8 Resolution
D. Alvaro ('01) 150 mg BID 20 49 × ULN 38 Resolution
Humayun ('07) 150 mg BID 180 20 × ULN 37 Death
  1. ULN = Upper limit of normal