Table 1 Published reports of bupropion hepatotoxicity
From: A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: Case report
Author (yr) | Dose | Duration of use (Days) | Peak ALT (IU/L) | Peak bilirubin (mg/dl) | Outcome |
|---|---|---|---|---|---|
Oslin ('93) | 300 mg QD × 21 days, then 400 mg QD | 54 | 5.4 × ULN | Not reported | Resolution |
Hu ('00) | 200 mg QD | 42 | 6660 | 3.8 | Resolution |
D. Alvaro ('01) | 150 mg BID | 20 | 49 × ULN | 38 | Resolution |
Humayun ('07) | 150 mg BID | 180 | 20 × ULN | 37 | Death |