Improvement of quality of life and survival using self-expandable metal stent placement for severe malignant stenosis of the gastric body: a case report
© Kumagai et al.; licensee BioMed Central Ltd. 2012
Received: 3 March 2012
Accepted: 19 July 2012
Published: 19 September 2012
Advanced gastric carcinoma often decreases quality of life because of upper gastrointestinal tract stenosis. Self-expandable metal stents have been thought to be an effective, minimally invasive treatment for stenosis. However, the effectiveness of self-expandable metal stent placement for carcinomatous stenosis of the gastric body and antrum has not been clarified, and there have been few reports of such cases.
A 74-year-old Japanese woman developed stenosis of the gastric body and antrum caused by advanced gastric cancer during first-line chemotherapy. She developed weight loss and poor nutrition due to inadequate intake. Self-expandable metal stent placement for stenosis of the gastric body and antrum ameliorated her symptoms rapidly and improved her general condition and quality of life. Eight days after self-expandable metal stent placement, second-line chemotherapy could be administered safely. Oral intake and nutritional status were maintained for 117 days after self-expandable metal stent placement, and she died of gastric cancer 176 days after self-expandable metal stent placement and initiation of second-line chemotherapy.
Self-expandable metal stent placement for carcinomatous stenosis in the gastric body and antrum could be an effective therapeutic strategy for patients with inadequate oral uptake. It may provide rapid improvement of the patient’s general condition and oral intake with minimal complications, comparatively long-term symptom relief, and a survival benefit by allowing second-line chemotherapy.
Advanced gastric carcinoma is a serious disease that not only has a poor prognosis but also decreases quality of life (QOL) because of upper gastrointestinal tract stenosis. Bypass surgery has been conventionally performed to relieve this condition and improve the QOL of these patients . Although palliative gastrostomy and ileostomy and gastric tube insertion have been performed for patients in poor general condition previously [2, 3] (many of whom could not undergo bypass surgery), self-expandable metal stents (SEMS) have been recognized as an effective, minimally invasive treatment in recent years [4–6]. SEMS are made of plastic materials and may be used to treat patients with malignant obstruction or external compression of the upper gastrointestinal tract, malignant gastrointestinal perforations, and selected cases of benign upper gastrointestinal disease. However, the effectiveness of SEMS placement for gastric carcinomatous stenosis with diffuse extensive cancer cell infiltration is unclear because there have been few reports of such cases. A case in which SEMS placement followed by second-line chemotherapy ameliorated gastric carcinomatous stenosis, gave comparatively long-term relief, and improved QOL is described here. The usefulness, safety, and problems of this treatment are discussed.
Our patient’s case showed progression of stenosis of the gastric body and antrum along with disease progression during first-line chemotherapy. Prompt amelioration of symptoms and improvement of her general condition were needed because our patient had developed weight loss and poor nutritional status due to inadequate oral uptake. There are several therapeutic options to facilitate oral uptake for patients with stenosis of the upper gastrointestinal tract, including chemotherapy, bypass surgery, and stent placement [5, 6]. Insertion of a nasogastric tube and gastrostomy enable only symptom relief by reducing pressure in the gastrointestinal tract [2, 3]. Although it has been estimated that SLC induces tumor response in 20% of cases, it might not permit immediate symptom relief [7–9]. In our patient’s case, bypass surgery was not possible because the infiltrating carcinomatous cells were distributed across a wide area of the stomach. We then considered stent placement in the upper gastrointestinal tract. A previous report proposed the indications and contraindications of SEMS for gastrointestinal tract stenosis . The indications were inoperable malignant gastro-duodenal outlet obstruction, extrinsic compression by neoplastic or nodal disease, anastomotic tumor recurrence after surgery, malignant fistula to adjacent organs, benign strictures refractory to balloon dilatation, and patients not being amenable to surgery. The contraindications were curable disease by multimodality treatment, uncorrectable coagulopathy, terminally ill patients with limited life expectancy, peritoneal carcinomatosis with distal small bowel obstruction, free gastrointestinal perforation, bowel ischemia, and sepsis. However, favorable sites for stenoses in the upper gastrointestinal tract for SEMS were not well defined, and there have been few reports of SEMS placement for wide stenotic lesions of the gastric body and antrum because SEMS had not been thought suitable for such cases [10, 11]. Our patient had stenosis of the gastric body and antrum, and SEMS placement was thought appropriate because the length of the stenotic region was 8 to 10cm (a length for which the device might be suitable), the pyloric ring was intact, and some space on the oral side of the stenotic region was available. Finally, stent placement was successfully performed, oral uptake recovered immediately, and our patient’s nutritional status also improved. Stent placement in the upper gastrointestinal tract could be appropriate even for patients with poor performance status and multiple complications because it is less invasive, has a good success rate, and provides rapid symptom relief. Meanwhile, adverse events, including bleeding in less than 1%, pain in 2.5%, perforation in <1%, biliary obstruction in 1.3%, and tumor ingrowth of the stent in 17% to 50%, have been reported . Stent migration also occurred in 0% to 5% with a bare-metal stent (BMS) and in 21% to 26% with a covered stent . Since various complications induced by stent placement often occur in the thoracic upper esophagus within 2cm of the esophageal entrance, esophago-gastric junction, pylorus ring, and ampulla of Vater, the location of stent placement requires careful consideration. Although our patient had stenosis of both the gastric body and the EGJ, with disease progression during first-line chemotherapy, stent placement was used only for the gastric body stenosis, not for the EGJ stenosis. The stenosis of the EGJ was mild and an endoscope could easily pass through the EGJ at that time. In addition, the longest length of WallFlex® Duodenal Stent does not have enough length to cover the distance from the lower esophagus to pre-pylorus. Moreover, stent placement at the EGJ was associated with a risk of stent migration or persistent pain, vomiting and esophagitis due to gastroesophageal reflux, because of expansion of a physically narrowing region. As mentioned above, complications related to stent placement in the EGJ, including dropout of the stent, gastroesophageal reflux, and aspiration pneumonia, have often been reported [12, 13]. Recently, an anti-reflux stent that is expected to prevent such complications, has been developed, and its practical effectiveness has been verified .
In our patient’s case, stent placement in the gastric body was an effective and durable treatment for the stenosis. Stent placement for stenosis of the esophagus and duodenum has been well documented, but few reports of stenting for gastric body stenosis were found. This might be because carcinomatous stenosis tends to appear in a wide area of the stomach involved with scirrhous type carcinomas. Severe stenosis localized to the gastric body or antrum could be a candidate for this intervention. Selecting appropriate cases and technical improvements could provide greater clinical benefit.
Since the survival benefit of SLC for metastatic gastric carcinoma (MGC) has been proven, it is often considered after failure of the prior chemotherapy [7, 8, 15]. In recent years, a phase III study showed that SLC with CPT-11 (Camptothecin-11 or Irinotecan) or docetaxel for MGC significantly improved overall survival (OS) compared with best supportive care (BSC) alone (5.1 months for SLC versus 3.8 months for BSC) . SLC with weekly paclitaxel has also been used based on a 16% to 24% tumor response, and overall survival ranged from 3.5 to 8.0 months in several phase II studies [7, 8]. In addition, the toxicity of the weekly paclitaxel regimen was generally feasible for patients with MGC, even with moderate carcinomatous ascites . A phase III study comparing bi-weekly CPT-11 (Camptothecin-11 or Irinotecan) and weekly paclitaxel as SLC for MGC has also been conducted in Japan. In our patient’s case, SLC with paclitaxel was safely performed, and it inhibited stenosis of the cardia and re-stenosis of the gastric body and antrum after stent placement, so that long-term oral uptake was achieved. Survival was longer than that reported in the previous report . No mechanical and symptomatic problems were found related to the stent placed in the gastric body and antrum. Severe stenosis of the gastrointestinal tract and fistula formation were often observed in patients with advanced gastrointestinal cancer. These diseases decrease oral uptake and performance status and induce infections such as pneumonia and abscesses. In these cases, it is often difficult to administer anti-cancer agents because of the patients’ poor general condition or the risk of exacerbating infections. However, immediate interventions, such as bypass surgery and stent placement, might make it possible not only to ameliorate symptoms, but also to provide a chance for systemic chemotherapy, resulting in comparative prolongation of survival.
SEMS placement for carcinomatous stenosis in the gastric body and antrum could be an effective therapeutic strategy for patients in poor general condition in whom bypass surgery is not appropriate. This approach may provide rapid improvement of symptoms, oral ingestion, prolong survival, and allow adequate systemic chemotherapy.
Written informed consent was obtained from the patient’s next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Jeurnink SM, van Eijck CH, Steyerberg EW, Kuipers EJ, Siersema PD: Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review. BMC Gastroenterol. 2007, 7: 18-10.1186/1471-230X-7-18.View ArticlePubMedPubMed CentralGoogle Scholar
- Pothuri B, Montemarano M, Gerardi M, Shike M, Ben-Porat L, Sabbatini P, Barakat RR: Percutaneous endoscopic gastrostomy tube placement in patients with malignant bowel obstruction due to ovarian carcinoma. Gynecol Oncol. 2005, 96: 330-334. 10.1016/j.ygyno.2004.09.058.View ArticlePubMedGoogle Scholar
- Soriano A, Davis MP: Malignant bowel obstruction: individualized treatment near the end of life. Cleve Clin J Med. 2011, 78: 197-206. 10.3949/ccjm.78a.10052.View ArticlePubMedGoogle Scholar
- Katsanos K, Sabharwal T, Adam A: Stenting of upper gastrointestinal tract: current status. Cardiovasc Intervent Radiol. 2010, 33: 690-705. 10.1007/s00270-010-9862-6.View ArticlePubMedGoogle Scholar
- Maetani I, Akatsuka S, Ikeda M, Tada T, Ukita T, Nakamura Y, Nagao J, Sakai Y: Self-expandable metallic stent placement for palliation in gastric outlet obstructions caused by gastric cancer: a comparison with surgical gastrojejunostomy. J Gastroenterol. 2005, 40: 932-937. 10.1007/s00535-005-1651-7.View ArticlePubMedGoogle Scholar
- Jeurnink SM, Steyerberg EW, van Hooft JE, van Eijck CH, Schwartz MP, Vleggaar FP, Kuipers EJ, Siersema PD, Dutch SUSTENT Study Group: Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial. Gastrointest Endosc. 2010, 71: 490-497. 10.1016/j.gie.2009.09.042.View ArticlePubMedGoogle Scholar
- Kodera Y, Ito S, Mochizuki Y, Fujitake S, Koshikawa K, Kanyama Y, Matsui T, Kojima H, Takase T, Ohashi N, Fujiwara M, Sakamoto J, Akimasa N, Chubu Clinical Cancer Group: A phase 2 study of weekly paclitaxel as second-line chemotherapy for advanced gastric cancer (CCOG0302 study). Anticancer Res. 2007, 27: 2667-2672.PubMedGoogle Scholar
- Hironaka S, Zenda S, Boku N, Fukutomi A, Yoshino T, Onozawa Y: Weekly paclitaxel as second line chemotherapy for advanced or recurrent gastric cancer. Gastric Cancer. 2006, 9: 14-18. 10.1007/s10120-005-0351-6.View ArticlePubMedGoogle Scholar
- Sakamoto J, Matsui T, Kodera Y: Paclitaxel chemotherapy for the gastric cancer. Gastric Cancer. 2009, 12: 69-78. 10.1007/s10120-009-0505-z.View ArticlePubMedGoogle Scholar
- Kim TO, Kang DH, Kim GH, Heo J, Song GA, Cho M, Kim DH, Sim MS: Self-expandable metallic stents for palliation patients with malignant gastric outlet obstruction caused by stomach cancer. World J Gastroenterol. 2007, 13: 916-920.View ArticlePubMedPubMed CentralGoogle Scholar
- Ajisaka H, Fujimura T, Fushida S, Yonemura Y, Miwa K: An indwelling expandable metallic stent for Borrmann type 4 gastric cancer with complete obstruction of the body. Gastroenterol Endosc. 2000, 42: 32-35.Google Scholar
- Homs MY, Wahab PJ, Kuipers EJ, Steyerberg EW, Grool TA, Haringsma J, Siersema PD: Esophageal stents with antireflux valve for tumors of the distal esophagus and gastric cardia: a randomized trial. Gastrointest Endosc. 2004, 60: 695-702. 10.1016/S0016-5107(04)02047-4.View ArticlePubMedGoogle Scholar
- Pabon ITP, Diaz LP, Adana JCR, Herrero JL: Gastric and duodenal stent: follow-up and complications. Cardiovasc Intervent Radiol. 2001, 24: 147-153. 10.1007/s002700001742.View ArticleGoogle Scholar
- Laasch HU, Marriott A, Wilbraham L, Tunnah S, England RE, Martin DF: Effectiveness of open versus antireflux stents for palliation of distal esophageal carcinoma and prevention of symptomatic gastroesophageal reflux. Radiology. 2002, 225: 359-365. 10.1148/radiol.2252011763.View ArticlePubMedGoogle Scholar
- Park SH, Lim DH, Park K, Lee S, Oh SY, Kwon H, Kang JH, Hwang IG, Lee J, Park JO, Park YS, Lim HY, Kang WK: A multicenter, randomized phase 3 trial comparing second-line chemotherapy (SLC) plus best supportive care (BSC) with BSC alone for pretreated advanced gastric cancer. J Clin Oncol. 2011, 29:
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