Teratoma of the lumbosacral region: a case report
© Faheem et al; licensee BioMed Central Ltd. 2011
Received: 28 October 2010
Accepted: 12 August 2011
Published: 12 August 2011
Teratoma is a tumor that usually arises from one or more germ layers. They are most commonly found in the sacrococcygeal region and have a female preponderance. We present a very rare case of a boy with a benign cystic teratoma in the lumbosacral region.
A 16-year-old Indian boy presented to our hospital with a history of a lump in the lower back region since birth. Initially, it was small, but its size increased gradually over time to a size of 15 cm × 15 cm at presentation. There were no other associated abnormalities. Investigations revealed the lump to be a benign cystic teratoma. The patient underwent surgery, and the whole tumor, from its base to the vertebrae, was excised. Bisection of the tumor revealed that it contained hair and pultaceous material consistent with a teratoma, which was later confirmed by histopathologic examination.
Benign cystic teratomas should be diagnosed and managed aggressively because they generally have a greater tendency to progress toward malignancy. After extensively searching the case report database, we arrived at the conclusion that this was a rare case of a benign cystic teratoma in the lumbosacral region in a boy.
Teratomas are germ cell tumors primarily composed of multiple types of cells derived from one or more of the three germ layers . The term "teratoma," which literally means "monster" in Greek, was coined by Virchow. Teratomas can be categorized into two types: mature and immature. Mature teratomas can further be classified as solid or cystic (dermoid cysts). A dermoid cyst is lined with epithelium that contains tissues and cells normally present in the skin layer, including hair follicles and sebaceous and sweat glands. The most common locations are the sacrococcygeal region (57%), followed by the gonads (29%), the mediastinal region (7%), the retroperitoneum (3%), the cervical area, and the cranium [2–4]. The "sacrococcygeal" term is a misnomer because teratomas almost always arise from the coccyx and not from the sacral region. Teratomas show a female preponderance at a ratio of four to one [5, 6]. However, the occurrence of a lumbosacral teratoma in a male patient is fairly rare. Hence, the present case report is intended to highlight this extremely rare occurrence regarding the tumor site.
The tumor was excised by creating an elliptical incision over the cyst. A whitish yellow, well-encapsulated, non-mobile mass was observed. The tumor was carefully dissected to allow us to reach the base, which was found to be attached to the L5 lumbar vertebra. The attachments, along with a small piece of lumbar vertebra, were also removed to minimize the chance of recurrence.
A teratoma is an encapsulated tumor with components resembling normal derivatives of all three germ layers . Teratomas usually arise as masses in the sacrococcygeal region . Their predilection for this area is most likely related to the large number of pluripotent cells usually found in the caudal region of the embryo, which is closely associated with the distal sacrum and coccyx. Being encapsulated, teratomas are usually benign, although sometimes malignant transformation may occur, mainly into squamous cell carcinoma [1, 8, 9]. It is therefore recommended that they be excised as soon as possible. A mature teratoma is typically benign and is found more commonly in females, but immature teratomas are typically malignant and are found more often in males.
The other differential diagnoses considered in this case were lumbosacral lipomeningomyelocele, congenital lipoma, and sacrococcygeal teratoma. Lipomeningomyeloceles commonly occur in the lumbosacral area, but the MRI examination of our patient revealed no communication with the spinal cord, so this possibility was ruled out . Similarly, congenital lipoma was also excluded from the differential diagnosis based on FNAC, which did not show any fat cells . A sacrococcygeal teratoma almost always arises from the coccyx and not from the sacral area, so this possibility was ruled out on the basis of the findings suggested by the clinical examination and MRI .
The diagnosis of a teratoma is based mainly on histopathologic examination, although MRI is also helpful in determining its connection with the vertebral column or its extension into the spinal cord. Prenatally, teratomas are usually diagnosed on the basis of obstetric ultrasonography in utero. They appear as a mixture of cystic and solid components. Recently, prenatal MRI has also been used in the imaging of antenatal fetal anomalies. Mothers carrying fetuses with cystic teratomas may develop polyhydramnios, which may lead to pre-term labor secondary to uterine distension. Volume reduction amniocentesis and tocolytics may be required to treat symptomatic polyhydramnios and prevent pre-term delivery . In this case, the mother of the patient had not undergone any prenatal ultrasonography since she was illiterate and was not aware of the importance of prenatal ultrasonography in diagnosing neural tube defect in utero so she did not turn up for ultrasonography. She did not develop any difficulties during labor.
Anatomic sites and sex distribution of teratomasa
Teratomas are usually benign but sometimes may occur as malignant tumors. To avoid any diagnostic dilemma, it is significant to understand the rare presentation with regard to the tumor site and the possibility of malignancy. The case history and the very rare site of the tumor described in this report will help clinicians in diagnosing such cases and will help in enhancing clinical knowledge and experience for better treatment and patient care.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Kumar V, Abbas AK, Fausto N: The Female Genital Tract. Pathologic Basis of Disease. 2006, St Louis: Elsevier, 1099-1110. 7
- Teratoma, Cystic. http://emedicine.medscape.com/article/281850-overview
- Barksdale EM, Obokhare L: Teratomas in infants and children. Curr Opin Pediatr. 2009, 21: 344-349. 10.1097/MOP.0b013e32832b41ee.View ArticlePubMed
- Azizkhan R, Caty MG: Teratomas in children. Curr Opin Pediatr. 1996, 8: 287-292. 10.1097/00008480-199606000-00018.View ArticlePubMed
- Legbo JN, Opara WE, Legbo JF: Mature sacrococcygeal teratoma: case report. Afr Health Sci. 2008, 8: 54-57.PubMed CentralPubMed
- Sacrococcygeal Teratoma. http://hcp.obgyn.net/ultrasound/content/article/1760982/1906534
- Krishan S, Solanki R, Sethi SK: Sacrococcygeal teratoma: role of ultrasound in antenatal diagnosis and management. JHK Coll Radiol. 2004, 7: 35-39.
- Shanbhogue LKR, Bianchi A, Doig CM, Gough DCS: Management of benign sacrococcygeal teratoma: reducing mortality and morbidity. Pediatr Surg Int. 1990, 5: 41-44.
- Terenziani M, D'Angelo P, Bisogno G, Boldrini R, Cecchetto G, Collini P, Conte M, De Laurentis T, Ilari I, Indolfi P, Inserra A, Pira L, Siracusa F, Spreafico F, Tamaro P, Lo Curto M: Teratoma with a malignant somatic component in pediatric patients: the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. Pediatr Blood Cancer. 2010, 54: 532-537.PubMed
- AANS: Tethered Spinal Cord Syndrome. http://www.aans.org/Patient%20Information/Conditions%20and%20Treatments/Tethered%20Spinal%20Cord%20Syndrome.aspx
- Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, Brunelle F, Le Merrer M, Giudicelli Y, Pichon J, Kleinknecht B, Nataf F: Congenital lumbosacral lipomas. Childs Nerv Syst. 1997, 13: 298-335. 10.1007/s003810050090.View ArticlePubMed
- Mahour GH: Sacrococcygeal teratomas. CA Cancer J Clin. 1988, 38: 362-367. 10.3322/canjclin.38.6.362.View ArticlePubMed
- Sharma AK, Sharma CS, Gupta AK, Sarin YK, Agarwal LD, Zaffar M: Teratoma in pediatric age group: experience with 75 cases. Indian Pediatr. 1993, 30: 689-694.PubMed
- Reid SA, Mickle JP: Myelomeningocele occurring within a lumbosacral teratoma: case report. Neurosurgery. 1985, 17: 338-340. 10.1227/00006123-198508000-00019.View ArticlePubMed
- Bucy PC, Haymond HE: Lumbosacral teratoma associated with spina bifida occulta: report of a case with review of the literature. Am J Pathol. 1932, 8: 339-346.PubMed CentralPubMed
- Sharma MC, Jain D, Sarkar C, Bhatnagar V, Rishi A, Suri V, Garg A: Lumbosacral Wilms' tumor as a component of immature teratoma associated with spinal dysraphism: a rare case and short literature review. Fetal Pediatr Pathol. 2009, 28: 201-208.View ArticlePubMed
- Ibrahim AE, Myles L, Lang DA, Ellison DW: Case of the month: June 1998. 2 year old boy with lumbosacral mass. Brain Pathol. 1998, 8: 817-818.PubMed
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