Lower respiratory tract infection and rapid expansion of an abdominal aortic aneurysm: a case report
© Naylor et al; licensee BioMed Central Ltd. 2010
Received: 7 December 2009
Accepted: 21 October 2010
Published: 21 October 2010
The rate of abdominal aortic aneurysm expansion is related to multiple factors. There is some evidence that inflammation can accelerate aneurysm expansion. However, the association between pulmonary sepsis and rapid abdominal aortic aneurysm expansion is rarely reported.
Here we present a case of a rapidly expanding abdominal aortic aneurysm in a 68-year-old Caucasian man with a concomitant lower respiratory tract infection and systemic sepsis requiring intensive monitoring and urgent endovascular intervention. Our patient had an uncomplicated post-operative recovery and a follow-up computed tomography scan at one month demonstrated no evidence of an endoleak.
This case highlights the potential association between pulmonary sepsis and rapid abdominal aortic aneurysm expansion. In such cases, a policy of frequent monitoring should be adopted to identify those patients requiring definitive management.
Studies suggest that an abdominal aortic aneurysm (AAA) expands on average at 0.25 cm per annum . This is proportional to the size of the AAA [2, 3], and has been linked to factors such as smoking, hypertension, advanced age and cardiac disease . There are rare reports that aneurysmal disease can expand in the presence of lung sepsis over a few months [5, 6]. The presence of pulmonary disease may increase inflammatory mediators and result in weakening of the aortic wall . Here we report the case of a sudden expansion of an infra-renal AAA in a patient with a lower respiratory tract infection (LRTI) and sepsis.
Despite aggressive treatment of our patient's pneumonia, he remained hypoxic. The options were either an emergency open bifurcated aortic graft or an endovascular aorto-uni-iliac repair with a femoral-to-femoral cross-over procedure. Following a full discussion with our patient, anesthetists and endovascular radiologists, the latter procedure was performed. Our patient had an uncomplicated post-operative recovery. He was continued on intravenous antibiotics for a further five days and discharged. He was followed up clinically at four, five and seven months post-operatively. CT scans at one and six months post-operatively showed good stent position and patency.
The expansion rate of AAAs varies according to numerous factors. The probability of rupture of a 5 cm and 7 cm AAA is less than 16% and 25% per year, respectively  and guidelines in the United Kingdom recommend three-monthly assessment with an abdominal ultrasound for AAAs greater than 5 cm . In small AAAs with a size of 3.0 to 3.9 cm growth, the growth rate has been reported as an average 0.11 cm annually . AAAs with a diameter of between 4.0 and 4.9 cm have been found to have a much larger rate of growth with an average rate of 0.79 cm per year in those with continuous expansion compared to 0.27 cm per year with discontinuous (staccato) expansion . Thus the typical expansion rate is about 0.25 cm per annum, and if the aneurysm diameter increases by 0.4 to 0.8 cm per year more frequent surveillance is recommended . AAA expansion varies individually and inflammation can influence this process and dramatically accelerate AAA expansion as a result of specific cellular immune responses [10, 11].
In the case presented here, the AAA had increased in size by about 0.3 cm per annum until admission. In the presence of concomitant sepsis it suddenly expanded. In the wall of an AAA there is up-regulation of pro-inflammatory IL-1β, IL-6, IL-10 and TNF-α, which have been shown to positively correlate with aneurysm growth [12, 13]. Such cytokines, chemokines and growth factors are known to be further potentiated during septic events such as a LRTI . One possibility is that concomitant sepsis could increase these specific inflammatory mediators within the AAA wall further weakening the aortic wall, increasing the risk of expansion and rupture.
There is a documented association between ongoing pulmonary sepsis, expansion of aortic aneurysms and aortic dissection [5, 15]. This has been more commonly reported in thoracic than AAAs. However, hematogenous seeding may also affect the abdominal aorta, if there is no contiguous focus of infection . The expansion and change in fat around the AAA found on the repeat CT aortogram suggested inflammation or an impending leak. In the case presented here, it is not clear whether this represented a mycotic AAA. However, the fusiform nature of the pre-existing AAA and lack of air in the aneurysm sac do not support a mycotic AAA. Regardless, there is controversy regarding the use of endovascular approaches in such aneurysms; however, there are several reports which demonstrate better outcomes when compared to conventional surgery in these high risk cases . Despite these concerns we proceeded with an endovascular repair, which was uneventful.
This case highlights the potential association between pulmonary sepsis and rapid AAA expansion. In these patients there must be a high index of clinical suspicion for rapid progression, and a policy of frequent monitoring may be adopted to identify those patients requiring definitive management. Endovascular repair may be suitable in certain cases depending on aneurysm morphology and local experience.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
abdominal aortic aneurysm
lower respiratory tract infection.
- Schlosser FJ, Tangelder MJ, Verhagen HJ, van der Heijden GJ, Muhs BE, van der Graaf Y, Moll FL: Growth predictors and prognosis of small abdominal aortic aneurysms. J Vasc Surg. 2008, 47: 1127-1133. 10.1016/j.jvs.2008.01.041.View ArticlePubMedGoogle Scholar
- Santilli SM, Littooy FN, Cambria RA, Rapp JH, Tretinyak AS, d'Audiffret AC, Kuskowski MA, Roethle ST, Tomczak CM, Krupski WC: Expansion rates and outcomes for the 3.0- cm to the 3.9- cm infrarenal abdominal aortic aneurysm. J Vasc Surg. 2002, 35: 666-671. 10.1067/mva.2002.121572.View ArticlePubMedGoogle Scholar
- Vega de Ceniga M, Gomez R, Estallo L, de la Fuente N, Viviens B, Barba A: Analysis of expansion patterns in 4-4.9 cm abdominal aortic aneurysms. Ann Vasc Surg. 2008, 22: 37-44. 10.1016/j.avsg.2007.07.036.View ArticlePubMedGoogle Scholar
- Chang JB, Stein TA, Liu JP, Dunn ME: Risk factors associated with rapid growth of small abdominal aortic aneurysms. Surgery. 1997, 121: 117-122. 10.1016/S0039-6060(97)90279-8.View ArticlePubMedGoogle Scholar
- Monaco M, Di Tommaso L, Oliviero U, Iannelli G, Stassano P: A rapidly expanding descending thoracic aortic aneurysm: an unusual complication. J Card Surg. 2008, 23: 260-261. 10.1111/j.1540-8191.2007.00525.x.View ArticlePubMedGoogle Scholar
- Kandpal H, Seith A: Rapidly enlarging mediastinal mass in a middle-aged patient with fever. Br J Radiol. 2008, 81: 357-359. 10.1259/bjr/35631387.View ArticlePubMedGoogle Scholar
- Kent KC, Zwolak RM, Jaff MR, Hollenbeck ST, Thompson RW, Schermerhorn ML, Sicard GA, Riles TS, Cronenwett JL: Screening for abdominal aortic aneurysm: a consensus statement. J Vasc Surg. 2004, 39: 267-269. 10.1016/j.jvs.2003.08.019.View ArticlePubMedGoogle Scholar
- Devaraj S, Dodds SR: Ultrasound surveillance of ectatic abdominal aortas. Ann R Coll Surg Engl. 2008, 90: 477-482. 10.1308/003588408X301064.View ArticlePubMedPubMed CentralGoogle Scholar
- Dehlin JM, Upchurch GR: Management of Abdominal Aortic Aneurysms. Curr Treat Options Cardiovasc Med. 2005, 7: 119-130. 10.1007/s11936-005-0013-3.View ArticlePubMedGoogle Scholar
- Shimizu K, Mitchell RN, Libby P: Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2006, 26: 987-994. 10.1161/01.ATV.0000214999.12921.4f.View ArticlePubMedGoogle Scholar
- Jagadesham VP, Scott DJ, Carding SR: Abdominal aortic aneurysms: an autoimmune disease?. Trends Mol Med. 2008, 14: 522-529.View ArticlePubMedGoogle Scholar
- Middleton RK, Lloyd GM, Bown MJ, Cooper NJ, London NJ, Sayers RD: The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: a protein array study. J Vasc Surg. 2007, 45: 574-580. 10.1016/j.jvs.2006.11.020.View ArticlePubMedGoogle Scholar
- Wallinder J, Bergqvist D, Henriksson AE: Proinflammatory and anti-inflammatory cytokine balance in patients with abdominal aortic aneurysm and the impact of aneurysm size. Vasc Endovascular Surg. 2009, 43: 258-261. 10.1177/1538574408324617.View ArticlePubMedGoogle Scholar
- Gallagher PM, Lowe G, Fitzgerald T, Bella A, Greene CM, McElvaney NG, O'Neill SJ: Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax. 2003, 58: 154-156. 10.1136/thorax.58.2.154.View ArticlePubMedPubMed CentralGoogle Scholar
- Mory M, Hansmann J, Allenberg JR, Bockler D: Images in vascular medicine. Rapid expansion of an inflammatory abdominal aortic aneurysm. Vasc Med. 2007, 12: 381-382. 10.1177/1358863X07083276.View ArticlePubMedGoogle Scholar
- Kan CD, Lee HL, Yang YJ: Outcome after endovascular stent graft treatment for mycotic aortic aneurysm: a systematic review. J Vasc Surg. 2007, 46: 906-912. 10.1016/j.jvs.2007.07.025.View ArticlePubMedGoogle Scholar
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