Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

Benign mesenteric lipodystrophy presenting as low abdominal pain: a case report

Journal of Medical Case Reports20104:119

DOI: 10.1186/1752-1947-4-119

Received: 4 November 2009

Accepted: 27 April 2010

Published: 27 April 2010



Benign mesenteric lipodystrophy is rare and often presents in a non-specific fashion. Imaging findings may mimic a range of malignant conditions, particularly malignant ovarian disease in women.

Case presentation

We present the case of a 61-year-old Caucasian woman who was referred to the gynaecology service at our institution and was thought to have ovarian malignancy, and required a laparotomy. However, histopathological analysis unexpectedly revealed benign mesenteric lipodystrophy.


Benign mesenteric lipodystrophy may mimic a range of conditions, particularly malignancy.


Benign mesenteric lipodystrophy is a rare condition with just over 200 cases being noted in the worldwide literature [1]. It was first described by Jura during the 1920s [2] and is characterized by non-specific inflammation involving the adipose tissue of the bowel mesentery [3]. It is commonly asymptomatic, or only noted during cross sectional imaging investigations that have been undertaken for other indications [4]. However, some patients present with symptoms that include abdominal tenderness or an abdominal mass while some may have abdominal pain, fever, a change in bowel habit and sometimes weight loss [5, 6].

Its etiology is unclear. However, previous trauma, mesenteric ischemia or infection have been suggested as potential causes. Other documented possible associations with this disease include tuberculosis [1], pancreatitis, malignant tumour particularly lymphoma, vasculitis and granulomatous diseases [7]. The histopathology of this condition, which is also called sclerosing mesenteritis, has been described in three phases. Initially, fat necrosis is seen, leading to the nomenclature of mesenteric lipodystrophy. This is then followed by mesenteric panniculitis, which is associated with profound inflammation. Finally, fibrosis supervenes with mesenteric retraction and shortening [4], hence the term 'sclerosing mesenteritis'. In many cases, histopathology shows changes consistent with all three histopathological phases as these changes appear to occur at differing rates in different areas of the mesentery [5]. Patients with a treatable cause, such as tuberculosis, have been described to have almost complete resolution of the intra-abdominal change when re-imaged [1] particularly in the mesenteric lipodystrophy phase of the condition. We describe a case mimicking ovarian malignancy.

Case presentation

A 61-year-old British Caucasian woman was initially referred to the gynecology service in our institution with low abdominal and pelvic pain. An initial clinical examination was unremarkable. However, a pelvic ultrasound scan was undertaken and revealed cystic masses within the pelvis. A potential diagnosis of ovarian malignancy was considered and computed tomography (CT) was then performed, which also suggested an intra-abdominal mass of possible ovarian origin (Figure 1). In view of these findings, our patient underwent a laparotomy. At this time, the ovaries were noted to be normal. However, the mesentery of the small bowel was found to have multiple large mesenteric masses (Figure 2). These involved the majority of the small bowel mesentery and were irresectable. Biopsies were taken at this time and the mesenteric masses were shown to be benign with no evidence of lymphoma or epithelial malignancy, but were diagnostic for the mesenteric lipodystrophy stage if the illness. Our patient had an uncomplicated post-operative course and was discharged after five days.
Figure 1

Coronal computed tomography images showing multiple solid and cystic intra-abdominal lesions marked with an arrow with associated calcification in the bowel wall.
Figure 2

Intra-operative photograph showing multiple small intestinal mesenteric masses. Suture line represents site of operative sample of one of the multiple masses.

A trial of tamoxifen 20 mg orally once daily was instituted in an attempt to reduce the size of the mesenteric masses. However, follow up CT of the abdomen did not shown any response after six months of therapy, so tamoxifen was discontinued. A follow-up small bowel study to exclude small bowel stricturing as a consequence of mesenteric fibrosis has not revealed any abnormality. Two years after the initial surgery, our patient remains well.


Benign mesenteric lipodystrophy is rare and has been described in most detail in a three-case series by Durst [6], Kipfer [7] and Emory [5] who together identify 165 patients. It is more common in men (2-3:1; M:F ratio), and affects a large age range from 20 to 80 years but is most common in individuals aged 50 to 60 years. It has a broad range of clinical presentations with at least half of those affected being asymptomatic. In these individuals, it is a usually found at the time of cross-section imaging, laparoscopy or laparotomy as in our case. The etiology of this condition is unclear. However, associations have been reported between mesenteric panniculitis and lymphoma [7] while an autoimmune etiology or as a response to ischaemia have also been postulated as possible causes [8, 9].

A range of symptoms are described, including most commonly undiagnosed abdominal pain, and more commonly diagnosed signs of gastrointestinal obstruction. Fever, weight loss, abdominal mass or even a protein-losing enteropathy have been described. The frequency of differing symptoms is unclear because of the rarity of the condition but most reports suggest that the initial presentation is either with abdominal pain or as an asymptomatic finding at cross-sectional imaging. Biochemical tests are usually unhelpful, while hematological investigations may only show anaemia or a raised erythrocyte sedimentation rate (ESR) but are non-specific.

CT may help in making the diagnosis of mesenteric lipodystrophy. There are a number of features on CT that may suggest mesenteric lipodystrophy. These include increased attenuation in the small bowel described by Seo et al. [10] as the 'misty mesentery' or in more advanced cases there may be a solid soft tissue mass, which surrounds the mesenteric vessels with preservation of the surrounding fat around a "fat ring sign" on CT image [11, 12].

The CT findings are unfortunately not specific and can mimic other lesions of the mesentery including lymphoma, lipoma, edema (of any etiology, for example heart failure, vasculitis, cirrhosis or hypoalbuminemia), tuberculosis, carcinomatosis or, very rarely, mesothelioma [10]. The extent of the change in the intra-abdominal fat may be wide-ranging and can include the mesocolon, mesoappendix, the peri-pancreatic region, the greater omentum and pelvic fat, which may explain why the differential diagnosis can be so extensive.

Diagnosis is usually during laparotomy, although it can also be done during biopsy at the time of laparoscopy or percutaneously [13, 14]. Resectional surgery is of limited value in this setting [6]. Although smaller lesions may be resected for diagnostic purposes, the diffuse involvement of the mesentery would mean that excessively long segments of small bowel would have to be removed to clear the bulk of the mesenteric change resulting in significant morbidity.

Histologically, the condition shows a progressive series of changes. However, the different histological stages often co-exist within the same specimen. Initially, the mesentry is infiltrated with lipid-filled macrophages within the fat-filled septa of the mesenteric adipose tissue, which is known as mesenteric lipodystrophy. As the condition progresses and inflammation supervenes, lymphocytes infiltrate the mesentery and lipid cystic necrosis can be identified. This is a change known as mesenteric panniculitis. Later, necrosis with associated fibrosis dominates. This is associated with shortening of the mesentery, and is called the retractile mesenteritis stage. Typically, these changes may be identified by H&E staining. However, in cases where there is diagnostic difficulty particularly, when differentiating mesenteric lipodystrophy from gastrointestinal stromal tumours.(GISTs) and mesenteric fibromatosis, Montgomery et al. suggest that immunohistochemistry using a panel of antibodies (CD117, beta-catenin, CD34, smooth muscle actin, desmin, keratin, and S-100 protein) may help differentiate the histological types [15].

Treatment of this condition depends on the stage of the disease: early changes are nearly always managed conservatively as the illness resolves in many individuals with the lipodystrophy phase without intervention. In the later panniculitis or fibrotic phases of the illness, a range of treatments have been investigated. To suppress inflammation, steroids, cyclophosphamide [8], azathioprine and colchicine, treatment successes have also been reported after the use of tamoxifen and oral progesterones [16]. However, if fibrosis occurs that leads to symptomatic strictures of the gastrointestinal tract, then surgical resection of the affected segment is indicated [17, 18].


Mesenteric lipodystrophy is a rare condition that can mimic a number of intra-abdominal conditions including ovarian pathology. It can be difficult to diagnose and is often only fully apparent at the time of laparoscopy or laparotomy. Histologically, it forms part of a continuum of inflammation and fibrosis and may often in the early stages resolve spontaneously. Although often unnecessary in the early stages, treatment may require immunosuppression or even resectional surgery in the later stages if the disease progresses.


Written informed consent was obtained from our patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the journal's Editor-in-Chief.



computerised tomography


erythrocyte sedimentation rate


Haematoxylin and Eosin


Gastrointestinal stromal tumours.


Authors’ Affiliations

Department of General Surgery, Gloucestershire Royal Hospital
Department of General Surgery, Great Western Hospital


  1. Ege G, Akman H, Cakiroglu G: Mesenteric panniculitis associated with abdominal tuberculous lymphadenitis: a case report and review of the literature. Br J Radiol. 2002, 75 (892): 378-380.View ArticlePubMedGoogle Scholar
  2. Jura V: Mesenterite retrattile-caso clinico: risultati sperimentali, rilievi patogenetici, considerazoni cliniche. Policlinico. 1927, 34: 535-556.Google Scholar
  3. Daskalogiannaki M, Voloudaki A, Prassopoulos P, Magkanas E, Stefanaki K, Apostolaki E, Gourtsoyiannis N: CT evaluation of mesenteric panniculitis: prevalence and associated diseases. AJR Am J Roentgenol. 2000, 174 (2): 427-431.View ArticlePubMedGoogle Scholar
  4. Vettoretto N, Diana DR, Poiatti R, Matteucci A, Chioda C, Giovanetti M: Occasional finding of mesenteric lipodystrophy during laparoscopy: a difficult diagnosis. World J Gastroenterol. 2007, 13 (40): 5394-5396.View ArticlePubMedPubMed CentralGoogle Scholar
  5. Emory TS, Monihan JM, Carr NJ, Sobin LH: Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity?. Am J Surg Pathol. 1997, 21 (4): 392-398. 10.1097/00000478-199704000-00004.View ArticlePubMedGoogle Scholar
  6. Durst AL, Freund H, Rosenmann E, Birnbaum D: Mesenteric panniculitis: review of the leterature and presentation of cases. Surgery. 1977, 81 (2): 203-211.PubMedGoogle Scholar
  7. Kipfer RE, Moertel CG, Dahlin DC: Mesenteric lipodystrophy. Ann Intern Med. 1974, 80 (5): 582-588.View ArticlePubMedGoogle Scholar
  8. Bush RW, Hammar SP, Rudolph RH: Sclerosing mesenteritis. Response to cyclophosphamide. Arch Intern Med. 1986, 146 (3): 503-505. 10.1001/archinte.146.3.503.View ArticlePubMedGoogle Scholar
  9. Hartz RSS, Sparberg M, Poticha SM: Mesenteric tumefaction. American Surgeon. 1980, 46: 525-529.PubMedGoogle Scholar
  10. Seo BK, Ha HK, Kim AY, Kim TK, Kim MJ, Byun JH, Kim PN, Lee MG, Yang SK, Yu ES, Kim JH: Segmental misty mesentery: analysis of CT features and primary causes. Radiology. 2003, 226 (1): 86-94. 10.1148/radiol.2261011547.View ArticlePubMedGoogle Scholar
  11. Horton KM, Lawler LP, Fishman EK: CT findings in sclerosing mesenteritis (panniculitis): spectrum of disease. Radiographics. 2003, 23 (6): 1561-1567. 10.1148/rg.1103035010.View ArticlePubMedGoogle Scholar
  12. Patel N, Saleeb SF, Teplick SK: General case of the day. Mesenteric panniculitis with extensive inflammatory involvement of the peritoneum and intraperitoneal structures. Radiographics. 1999, 19 (4): 1083-1085.View ArticlePubMedGoogle Scholar
  13. Weiser J, Salky B, Slepian A, Dikman S: Laparoscopic diagnosis of retractile mesenteritis. Gastrointest Endosc. 1992, 38 (5): 615-617. 10.1016/S0016-5107(92)70534-3.View ArticlePubMedGoogle Scholar
  14. Rajendran B, Duerksen DR: Retractile mesenteritis presenting as protein-losing gastroenteropathy. Can J Gastroenterol. 2006, 20 (12): 787-789.View ArticlePubMedPubMed CentralGoogle Scholar
  15. Montgomery E, Torbenson MS, Kaushal M, Fisher C, Abraham SC: Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis. Am J Surg Pathol. 2002, 26 (10): 1296-1301. 10.1097/00000478-200210000-00006.View ArticlePubMedGoogle Scholar
  16. Colomer Rubio E, Blanes Gallego A, Carbonell Biot C, Villar Grimalt A, Tomas Ivorra H, Llamusi Lorente A: Mesenteric panniculitis with retroperitoneal involvement resolved after treatment with intravenous cyclophosphamide pulses. An Med Interna. 2003, 20 (1): 31-33.PubMedGoogle Scholar
  17. Parra-Davila E, McKenney MG, Sleeman D, Hartmann R, Rao RK, McKenney K, Compton RP: Mesenteric panniculitis: case report and literature review. Am Surg. 1998, 64 (8): 768-771.PubMedGoogle Scholar
  18. Shah D, Patel S, Shah S, Goswami K: Mesenteric panniculitis a case report and review of the literature. Indian J Radiol Imag. 2005, 64: 768-771.Google Scholar


© Rees and Burgess; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.