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  1. Complex orthoplastic lower limb trauma in individuals with multiple injuries requires considerable resources and interdisciplinary collaboration for good outcomes. We present the first reported end-to-side fre...

    Authors: Dallan Dargan, Raghuram Lakshminarayan and Cher Bing Chuo
    Citation: Journal of Medical Case Reports 2021 15:601
  2. Adult patients with coronavirus disease present primarily with respiratory symptoms, but children and some adults may display a more systemic inflammatory syndrome with rash, fever, mucosal changes, and elevat...

    Authors: Catherine A. Gao, James M. Walter and Jane E. Dematte D’Amico
    Citation: Journal of Medical Case Reports 2021 15:590
  3. Psychiatric disorders increase risk of neuropsychiatric disease and poor outcomes, yet little is known about the neuropsychiatric manifestations of COVID-19 in the psychiatric population. The primary objective...

    Authors: Emma A. van Reekum, Tea Rosic, Anjali Sergeant, Nitika Sanger, Myanca Rodrigues, Reid Rebinsky, Balpreet Panesar, Eve Deck, Nayeon Kim, Julia Woo, Alessia D’Elia, Alannah Hillmer, Alexander Dufort, Stephanie Sanger, Lehana Thabane, Lawrence Mbuagbaw…
    Citation: Journal of Medical Case Reports 2021 15:586
  4. Viewing the existing literature, one can find several documents about dislocation of the peroneal tendons. Clinical findings, diagnostics, and therapy are well described. Instead, the list of documents describ...

    Authors: Johannes Riecke, Max Müller, Andreas Bölderl and Konstantin Genelin
    Citation: Journal of Medical Case Reports 2021 15:585
  5. Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality.

    Authors: Manana Dewage Sankani Vishvara Kularathna, Senanayake Abeysinghe Mudiyanselage Kularatne, Manoji Pathirage and Pala Thanthirige Madhushi Anuradha Nanayakkara
    Citation: Journal of Medical Case Reports 2021 15:584
  6. Aplastic anemia is an intractable disease characterized by pancytopenia, susceptibility to infection, and difficulty in achieving hemostasis. In patients with severe periodontal disease and aplastic anemia, sp...

    Authors: Satoru Morikawa, Kazuya Watanabe, Satoshi Usuda, Yoko Miyashita and Taneaki Nakagawa
    Citation: Journal of Medical Case Reports 2021 15:581
  7. Methotrexate is an anticancer drug from the antimetabolite class. It is also used in gynecology and obstetrics and is the molecule of choice for the medical treatment of ectopic pregnancies. We report a case o...

    Authors: Valéry Refeno, Naharisoa Giannie Rasamimanana, Baco Abdallah Abasse, Malalafinaritra Patrick Marco Ramarokoto, Mahefaniaina Jean Eustache Fanomezantsoa and Pierana Gabriel Randaoharison
    Citation: Journal of Medical Case Reports 2021 15:579
  8. Tuberculosis continues to be a worldwide public health problem. Despite the noted gradual decline in tuberculosis case rates in the UK, clinicians should still be aware of these unusual presentations. Sternal ...

    Authors: John Rajan and Khaled Bizanti
    Citation: Journal of Medical Case Reports 2021 15:580
  9. Rheumatoid arthritis is a common autoimmune disease with many extra-articular manifestations. Pure red cell aplasia is a rare manifestation of rheumatoid arthritis and is sparsely documented in the literature,...

    Authors: Suneth Weerasinghe, Parackrama Karunathilake, Udaya Ralapanawa, Thilak Jayalath, Shamali Abeygunawardena and Manel Rathnayaka
    Citation: Journal of Medical Case Reports 2021 15:578
  10. Rhabdomyolysis is defined as a syndrome consisting of muscle necrosis and the release of intracellular muscle components into the bloodstream. Although rhabdomyolysis has been previously reported as an initial...

    Authors: Goar Egoryan, Sana Chaudry, Kritika Yadav, Tianyu Dong, Emre Ozcekirdek, Ece Ozen and Guillermo Rodriguez-Nava
    Citation: Journal of Medical Case Reports 2021 15:576
  11. Rabies, caused by a lyssavirus, is a viral zoonosis that affects people in many parts of the world, especially those in low income countries. Contact with domestic animals, especially dogs, is the main source ...

    Authors: Y. A. Amoako, P. El-Duah, A. A. Sylverken, M. Owusu, R. Yeboah, R. Gorman, T. Adade, J. Bonney, W. Tasiame, K. Nyarko-Jectey, T. Binger, V. M. Corman, C. Drosten and R. O. Phillips
    Citation: Journal of Medical Case Reports 2021 15:575
  12. Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy.

    Authors: Huiping Li, Fang Yuan, Yaming Du, Tao Pan, Wanxin Wen, Shaoxue Li, Lixin Wang and Aili Lu
    Citation: Journal of Medical Case Reports 2021 15:574
  13. Uterine sarcoma accounts for 3–7% of uterine malignant neoplasms. It is more aggressive than epithelial neoplasms, and patients have a poor prognosis. Rhabdomyosarcoma is classified as a heterologous uterine s...

    Authors: Soheila Aminimoghaddam, Ali Rahbari and Roghayeh Pourali
    Citation: Journal of Medical Case Reports 2021 15:570
  14. In recent years, numerous studies have reported the development or exacerbation of sarcoidosis due to interferon therapy. However, ocular lesions rarely present as initial symptoms. Herein, we describe a rare ...

    Authors: Ai Kato, Mami Ishihara and Nobuhisa Mizuki
    Citation: Journal of Medical Case Reports 2021 15:568
  15. In neonates, rhesus D alloimmunization despite anti-D immunoglobulin prophylaxis is rare and often unexplained. Rhesus D alloimmunization can lead to hemolytic disease of the newborn with anemia and unconjugat...

    Authors: Sandra Simony Tornoe Riis, Marianne Hoerby Joergensen, Kristina Fruerlund Rasmussen, Steffen Husby, Jane Preuss Hasselby, Lise Borgwardt, Klaus Brusgaard, Christina Ringmann Fagerberg and Henrik Thybo Christesen
    Citation: Journal of Medical Case Reports 2021 15:573
  16. Hydroxychloroquine and chloroquine have been used for hospitalized coronavirus disease 2019 patients because of their antiviral and anti-inflammatory function. However, little research has been published on th...

    Authors: Astrid Muyldermans, Piet Maes, Tony Wawina-Bokalanga, Tine Anthierens, Olivier Goldberg, Magali Bartiaux, Oriane Soetens, Ingrid Wybo, Sigi Van den Wijngaert and Denis Piérard
    Citation: Journal of Medical Case Reports 2021 15:572
  17. Nephrotic-range proteinuria is a common reason for nephrological consultation in clinical practice. The differential diagnosis is wide, and generally focuses on different forms of glomerulonephritis, but other...

    Authors: Yana Apostolova, Patricia Mehier, Salah D. Qanadli and Menno Pruijm
    Citation: Journal of Medical Case Reports 2021 15:569
  18. Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is...

    Authors: Mahdane Roshani, Alireza Goodarzi, Sanaz Dehbashi, Farhad Afrasiabi, Hossein Goudarzi, Ali Hashemi and Mohammad Reza Arabestani
    Citation: Journal of Medical Case Reports 2021 15:567
  19. Patients diagnosed with locally advanced pancreatic cancer are usually not eligible for surgical resection because of significant vascular involvement. Stereotactic body radiation therapy and chemotherapy are ...

    Authors: Sriram Rao, Thanh-Lan Bui, Ali Sasani, Ben Sadeghi, Anvesh Macherla, Roozbeh Houshyar and Nadine Abi-Jaoudeh
    Citation: Journal of Medical Case Reports 2021 15:566
  20. Excipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties of low toxicity and hypoallergenicity. The excipient carboxymethylcellulose is used extensively as a thick...

    Authors: Katherine Townsend, James Laffan and Grant Hayman
    Citation: Journal of Medical Case Reports 2021 15:565
  21. Severe acute respiratory syndrome coronavirus 2, the cause of coronavirus disease 2019, has become a global pandemic. Currently, there is no definitive treatment for coronavirus disease 2019. Convalescent plas...

    Authors: Theresia Monica Rahardjo, Elizabeth Yogipranata, Ardian Hediyanto Naswan, Fitri Rahayu Sari, Fajar Budiono, Hernawati Permatasari and C. H. R. Driantik Chuntari
    Citation: Journal of Medical Case Reports 2021 15:564
  22. Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2, has a broad clinical spectrum, from asymptomatic to multi-organ dysfunction. Acute cerebrovascular events associated wit...

    Authors: Khurram Khaliq Bhinder, Ahsun Rizwan Siddiqi, Muhammad Junaid Tahir, Hamza Maqsood, Irfan Ullah and Zohaib Yousaf
    Citation: Journal of Medical Case Reports 2021 15:563
  23. The discovery of epidermal growth factor receptor oncogenic driver mutations has changed the therapeutic landscape of advanced non-small cell lung cancer in the past decade. Since the introduction of next-gene...

    Authors: Lander Van Acker, Dieter Stevens, Karim Vermaelen and Veerle Surmont
    Citation: Journal of Medical Case Reports 2021 15:562
  24. Adult-onset leukoencephalopathies are a group of heterogeneous disorders characterized by white matter abnormalities. Leukoencephalopathy is usually encountered in children, but here we report a case with adul...

    Authors: Mohamed A. Taha and T. Scott Diesing
    Citation: Journal of Medical Case Reports 2021 15:561
  25. Carney’s triad is a rare syndrome comprising gastrointestinal stromal tumor, extra-adrenal paraganglioma, and pulmonary chondroma along with newer additions of adrenal adenoma and esophageal leiomyoma. The tri...

    Authors: Ghazal Tansir, Nihar Ranjan Dash, Saurabh Galodha, Prasenjit Das, Shamim Ahmed Shamim and Sameer Rastogi
    Citation: Journal of Medical Case Reports 2021 15:559
  26. The new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) owing to its similarity to the previous severe acute respiratory syndrome (SARS), is characterized by causing, in most...

    Authors: Natalia Ramirez, David Ujueta, Luis Felipe Diaz, Lucila Emilse Folleco, Andrea Rodríguez, Ivan Gaona and Mauricio O. Nava-Mesa
    Citation: Journal of Medical Case Reports 2021 15:558
  27. Pneumatosis intestinalis is a rare disease characterized by gas-filled cysts within the submucosa or serosa of the intestinal tract. In recent years, pneumatosis intestinalis was reported in patients undergoin...

    Authors: Soji Toda, Hiroyuki Iwasaki, Daisuke Murayama, Maya Isoda, Hirotaka Nakayama, Nobuyasu Suganuma and Katsuhiko Masudo
    Citation: Journal of Medical Case Reports 2021 15:556
  28. Severe acute respiratory syndrome coronavirus 2 reinfection prevalence is unknown. It is essential to understand reinfection symptoms and, importantly, the lived experience.

    Authors: Jacinda K. Dariotis, Stephanie M. Sloane and Rebecca Lee Smith
    Citation: Journal of Medical Case Reports 2021 15:557
  29. Pituitary metastases are rare, often deriving from lung or breast cancer owing to the upper vena cava proximity. Pituitary metastases can manifest with signs and symptoms of pituitary tumors, consequent to mas...

    Authors: Giuseppe Giuffrida, Francesco Ferraù, Ylenia Alessi and Salvatore Cannavò
    Citation: Journal of Medical Case Reports 2021 15:555
  30. Sigmoid volvulus in pregnancy is a rare cause of intestinal obstruction with high maternal and fetal morbidity and mortality if not diagnosed and managed early.

    Authors: Jay Lodhia, Joachim Magoma, Joylene Tendai, David Msuya, Jamil Suleiman and Kondo Chilonga
    Citation: Journal of Medical Case Reports 2021 15:554
  31. Progressive pseudorheumatoid dysplasia is a rare, autosomal recessively inherited, noninflammatory musculoskeletal disorder caused by mutations occurring in the WNT1-inducible signaling pathway protein 3 gene....

    Authors: Anjumanara Anver Omar, Salman Ahmed, John Chris Rodrigues, Allan Kayiza and Lawrence Owino
    Citation: Journal of Medical Case Reports 2021 15:551
  32. Primary myelofibrosis is a rare myeloproliferative disorder in middle-aged and old adults and should be distinguished from secondary and reactive causes of bone marrow fibrosis because, in reactive fibrosis, t...

    Authors: Mahdi Khatuni, Marziyeh Ghalamkari, Fereshteh Ameli and Habibeh Yekehtaz
    Citation: Journal of Medical Case Reports 2021 15:550
  33. The aim of this study is to highlight the importance of having a central case managing team and to make some strong recommendations that can have a positive impact on the lives of hematopoietic stem cell trans...

    Authors: Jaleel Mohammed, Hadeel R. Bakhsh, Cliodhna Craig and Shahrukh K. Hashmi
    Citation: Journal of Medical Case Reports 2021 15:549
  34. Over-the-counter medication overdose is a difficult diagnostic challenge for many physicians as common drug screening assays cannot detect these substances. We present a case of acute psychosis, serotonin synd...

    Authors: Roudi Bachar, John Robert Majewski, Christopher Shrack and Anthony El-Khoury
    Citation: Journal of Medical Case Reports 2021 15:548
  35. The symptoms of coronavirus disease 2019, caused by the novel severe acute respiratory syndrome coronavirus 2, were originally assumed to be mainly respiratory. With increasing knowledge, however, it turned ou...

    Authors: A. Saleh, R. Jung, S. Tonner, F. Hornof and M. Strittmatter
    Citation: Journal of Medical Case Reports 2021 15:547
  36. Dieulafoy’s lesion, first found by Paul Georges Dieulafoy, is an infrequent but important cause of recurrent upper gastrointestinal bleeding. The bleeding is usually severe, but patients rarely present with ch...

    Authors: Javad Salimi, Mohamad Behzadi, Alireza Ramandi, Mehdi Jafarinia, Hamid Zand and Mohammad Pirouzian
    Citation: Journal of Medical Case Reports 2021 15:545
  37. This report describes the case of a patient whose pituitary microadenoma resolved after he contracted coronavirus disease 2019. To our knowledge, this is one of the first reported cases of pituitary tumor reso...

    Authors: Salah Raishan, Mohammed Alsabri, Ann Mary Hanna and Matthew Brett
    Citation: Journal of Medical Case Reports 2021 15:544
  38. Hodgkin lymphoma is a systemic disease that commonly involves the cervical, supraclavicular, and mediastinal lymph nodes. The involvement of central nervous system in Hodgkin lymphoma is extremely rare, and di...

    Authors: Shanila Ahmed, Babar Irfan, Muhammad Raza and Ghulam Haider
    Citation: Journal of Medical Case Reports 2021 15:532
  39. Pericardial neoplastic involvement is rarely related to primary tumors of the pericardium and is most often caused by spread from other primary sites, such as lung and breast carcinomas, hematological malignan...

    Authors: Milena Brachmans Mascarenhas Neves, Mirella Velasco Stival, Yuri Costa Sarno Neves, Jordânia Gonçalves Pereira da Silva, Daniela Borges da Rocha Macedo, Bianca Mendes Carnevalli, Alana Moura Fé e Silva, Claudia Vaz de Melo Sette, Stephane Tomaz da Luz and Daniel de Iracema Gomes Cubero
    Citation: Journal of Medical Case Reports 2021 15:543
  40. Being expressed in all stages of B-cell development and having a significant value on the European Group for the Immunological Characterization of Acute Leukemias scoring system, CD79a is considered as an exce...

    Authors: A. Berhili, M. Bensalah, J. ElMalki, A. Elyagoubi and R. Seddik
    Citation: Journal of Medical Case Reports 2021 15:531
  41. Neuroendocrine tumors are rare, heterogeneous neoplasms that produce a wide variety of clinical symptoms. Diarrhea in neuroendocrine tumors is incredibly common and is usually benign in nature. We report two e...

    Authors: Emma Gordon, David L. Chan, Jennifer Arena, Elizabeth Bernard, Emily Carr-Boyd, Stephen J. Clarke, Malinda Itchins, Diana Learoyd, Neomal Sandanayake and Nick Pavlakis
    Citation: Journal of Medical Case Reports 2021 15:542
  42. Desmoid-type fibromatosis is a rare disease that can result in hydronephrosis. Hydronephrosis associated with desmoid-type fibromatosis often requires surgery or ureteral stent insertion. Although radiation th...

    Authors: Yojiro Ishikawa, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Kazuya Takeda, Yu Suzuki and Keiichi Jingu
    Citation: Journal of Medical Case Reports 2021 15:540
  43. Streptococcus gallolyticus subspecies gallolyticus is a known pathogen that causes infective endocarditis, and most cases involve the left heart valves. We present the first reported case of prosthetic tricuspid ...

    Authors: Raz Shapira, Tamir Weiss, Elad Goldberg, Eytan Cohen, Ilan Krause, Ram Sharony and Idan Goldberg
    Citation: Journal of Medical Case Reports 2021 15:528
  44. Emerging reports are describing stroke in young, otherwise healthy patients with coronavirus disease 2019, consistent with the theory that some of the most serious complications of coronavirus disease 2019 are...

    Authors: Nicolas Koslover, Marc Hardwick, Alexander Grundmann and Tamara Levene
    Citation: Journal of Medical Case Reports 2021 15:538

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