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  1. Cholesteatomas are benign tumors mainly composed of cholesterol crystals that rarely arise within the orbit. However, orbital cholesteatomas require a complete surgical resection due to their recidivating pote...

    Authors: Parménides Guadarrama-Ortiz, José Alberto Choreño-Parra, Francisco Javier Pacheco-Sánchez, Alberto Iván Rodríguez-Nava, Gabriela García-Quintero, Patricia Emilia Rodríguez-Muñoz, Carlos Sánchez-Garibay and Manuel Ángeles-Castellanos

    Citation: Journal of Medical Case Reports 2021 15:18

    Content type: Case report

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  2. Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin. Despite being considered one of the main causes of metabolic acidosis, the association between an anion gap and MA...

    Authors: Jesus Ruiz-Ramos, Laura Lozano-Polo, Ana Juanes-Borrego, Iván Agra-Montava, Mireia Puig-Campmany and María Antonia Mangues-Bafalluy

    Citation: Journal of Medical Case Reports 2021 15:17

    Content type: Case report

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  3. Leiomyosarcomas are rare malignant tumors which originate from smooth muscle cells and very seldom give rise to intracerebral metastases. Nearly all cases of intracranial metastases stem from leiomyosarcomas o...

    Authors: Eric Dietel, Ulf Nestler, Hans Nenning, Christian Eisenlöffel, Ruth Stassart and Jürgen Meixensberger

    Citation: Journal of Medical Case Reports 2021 15:14

    Content type: Case report

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  4. Invasive mole is a subtype of gestational trophoblastic neoplasms (GTNs) that usually develops from the malignant transformation of trophoblastic tissue after molar evacuation. Invasive moles mostly occur in w...

    Authors: Sawsan Ismail, Karen Mikhael, Nehad Salloum and Zuheir Alshehabi

    Citation: Journal of Medical Case Reports 2021 15:13

    Content type: Case report

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  5. Caffeine is a widely used dietary stimulant, and cases of caffeine overdoses, sometimes leading to death, are increasing. We encountered a case of caffeine intoxication resolved with administration of the seda...

    Authors: Teppei Kitano, Masaki Okajima, Koji Sato, Toru Noda and Takumi Taniguchi

    Citation: Journal of Medical Case Reports 2021 15:11

    Content type: Case report

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  6. Hyperreflective lesions at the level of ganglion cell (GCL) and inner plexiform retinal layers (IPL) by optical coherence tomography (OCT) and cotton wool spots in the examination of the eye fundus have recent...

    Authors: José M. Ortiz-Egea, Jorge Ruiz-Medrano and José M. Ruiz-Moreno

    Citation: Journal of Medical Case Reports 2021 15:15

    Content type: Case report

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  7. Intestinal obstruction due to internal herniation of the bowel is a rare clinical entity which is often overlooked in the differential diagnosis of patients with abdominal pain who have no previous history of ...

    Authors: P. K. B. S. C. Bandara, A. M. Viraj Rohana and Aloka Pathirana

    Citation: Journal of Medical Case Reports 2021 15:10

    Content type: Case report

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  8. Glomus tumors are soft tissue neoplasms comprised of glomus cells, vasculature, and smooth muscle cells, which occur commonly in a single subungual area of the digits, and their main clinical features include ...

    Authors: Yuji Akechi, Shiroh Miura, Masayuki Ochi, Moe Enoki, Takuya Matsuda, Riko Kitazawa, Taketsugu Fujibuchi, Hirofumi Ochi, Michiya Igase and Yasumasa Ohyagi

    Citation: Journal of Medical Case Reports 2021 15:8

    Content type: Case report

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  9. Ovarian torsion is a gynecological surgical emergency whose diagnosis remains a challenge. Torsion occurs most frequently in women of reproductive age. It is usually associated with the presence of benign mass...

    Authors: Ana Patrícia Vicente, Andrea Sousa Gomes, Ligita Jokubkiene and Povilas Sladkevicius

    Citation: Journal of Medical Case Reports 2021 15:7

    Content type: Case report

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  10. Treatment options for chronic osmotic demyelination syndrome are limited to case reports and only a very few show complete recovery. We report a case of complete recovery of chronic osmotic demyelination syndr...

    Authors: Maheshi Wijayabandara, Shenal Appuhamy, Praveen Weerathunga and Thashi Chang

    Citation: Journal of Medical Case Reports 2021 15:6

    Content type: Case report

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  11. Familial chylomicronemia is an extremely rare disease. Lipoprotein lipase deficiency, lipoprotein defect or lipoprotein receptor defect are the main genetic causes of familial chylomicronemia.

    Authors: Ammu Thampi Susheela, Padmesh Vadakapet, Lekshmi Pillai and Susheela Thampi

    Citation: Journal of Medical Case Reports 2021 15:5

    Content type: Case report

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  12. Breast cancer is one of the most common causes of brain metastases. However, the presence of isolated central nervous system (CNS) metastatic disease early in the course of disease relapse is a rare event in c...

    Authors: Sandipkumar H Patel, Yoshihito David Saito, Zaibo Li, Bhuvaneswari Ramaswamy, Andrew Stiff, Mahmoud Kassem and Robert Wesolowski

    Citation: Journal of Medical Case Reports 2021 15:4

    Content type: Case report

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  13. TAFRO (thrombocytopenia, anasarca, fever, renal insufficiency or reticulin fibrosis, and organomegaly) syndrome is a recently recognized disease with a variety of presentations of variable severity. In acute s...

    Authors: Shogo Minomo, Yu Fujiwara, Shota Sakashita, Akito Takamura and Kaoru Nagata

    Citation: Journal of Medical Case Reports 2021 15:3

    Content type: Case report

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  14. Clostridium difficile (C. difficile) is a common cause of infectious colitis in individuals with prior antibiotic or hospital exposure. Extraintestinal manifestations of C. difficile infections, however, are rare...

    Authors: Charles Dac Pham and Duong Tommy Hua

    Citation: Journal of Medical Case Reports 2021 15:2

    Content type: Case report

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  15. To date, there are only a few case reports of cyclophosphamide (Cy)-induced hemorrhagic cystitis (HC) in adult or pediatric allogeneic stem cell transplant (SCT) patients treated successfully with hyperbaric o...

    Authors: Moayed Ibrahim, Kshama Bhyravabhotla, Basil Khalaf, Keith Van Meter, Nakhle S. Saba, Hana Safah and Francisco Socola

    Citation: Journal of Medical Case Reports 2021 15:1

    Content type: Case report

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  16. In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 ...

    Authors: Maria Chiara Pelle, Bruno Tassone, Marco Ricchio, Maria Mazzitelli, Chiara Davoli, Giada Procopio, Anna Cancelliere, Valentina La Gamba, Elena Lio, Giovanni Matera, Angela Quirino, Giorgio Settimo Barreca, Enrico Maria Trecarichi and Carlo Torti

    Citation: Journal of Medical Case Reports 2020 14:246

    Content type: Case report

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  17. Whereas lymphoma of the female breast is already rare, lymphoma of the male breast has only anecdotally been reported. Within a study of 32 lymphoma of the breast reported between 1973 and 2014 as Burkitt lymp...

    Authors: Shaymaa Elgaafary, Inga Nagel, Cristina López, Susanne Bens, Monika Szczepanowski, Rabea Wagener, Wolfram Klapper and Reiner Siebert

    Citation: Journal of Medical Case Reports 2020 14:245

    Content type: Case report

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  18. The application of laparoscopic surgeries has been increasing, and various uterine diseases in addition to leiomyoma/adenomyoma have become indications for total laparoscopic hysterectomy (TLH). Therefore, dat...

    Authors: Wataru Isono, Akira Tsuchiya, Michiko Honda, Ako Saito, Hiroko Tsuchiya, Reiko Matsuyama, Akihisa Fujimoto, Masashi Kawamoto and Osamu Nishii

    Citation: Journal of Medical Case Reports 2020 14:243

    Content type: Research article

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  19. Developing therapeutic strategies for a SARS-CoV-2 infection is challenging, but first the correct diagnosis has to be made. Unspecific upper and lower respiratory tract symptoms can be misleading; hence, a na...

    Authors: Felix S. Seibert, Daniela Toma, Frederic Bauer, Krystallenia Paniskaki, Moritz Anft, Benjamin J. Rohn, Simon Wang, Diana Racovitan, Nina Babel and Timm H. Westhoff

    Citation: Journal of Medical Case Reports 2020 14:242

    Content type: Case report

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  20. Acute paraquat ingestion remains a leading cause of mortality in developing countries. There is currently no evidence that treatment with high-dose immunosuppressants and antioxidants improves survival in pati...

    Authors: Maria A. Montoya-Giraldo, Luisa F. Díaz, Ubier E. Gómez, Juliana Quintero and Andres F. Zuluaga

    Citation: Journal of Medical Case Reports 2020 14:240

    Content type: Case report

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  21. Mismatch-repair-deficiency resulting in microsatellite instability (MSI) may confer increased radiosensitivity in locally advanced/metastatic tumors and thus radiotherapy (RT) potentially might have a changing...

    Authors: Giovanni Aluisio, Ercole Mazzeo, Frank Lohr, Federica Fiocchi, Stefania Bettelli, Cinzia Baldessari, Maurizio Paterlini and Alessio Bruni

    Citation: Journal of Medical Case Reports 2020 14:239

    Content type: Case report

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  22. Pyometrocolpos is accumulation of infected fluid in the uterus and vagina. It is rare in children, mostly seen after menarche as a result of obstructive congenital genital malformation that impairs free draina...

    Authors: Richard Kiritta, Georgina Balyorugulu, Maimuna Ahmed, Frank Christopher, Andrea Solnes Miltenburg and Albert Kihunrwa

    Citation: Journal of Medical Case Reports 2020 14:237

    Content type: Case report

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  23. Pneumothorax is defined as the presence of air or gas in the pleural cavity. Secondary pneumothorax usually occurs in patients with overt underlying lung disease, most commonly chronic obstructive pulmonary di...

    Authors: Yuto Kato, Miyuki Okuda, Koji Fukuda, Nobuya Tanaka and Seiichi Nobuyama

    Citation: Journal of Medical Case Reports 2020 14:236

    Content type: Case report

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  24. Pseudobulbar affect is a very distressing and underdiagnosed neuropsychiatric disorder that causes contextually inappropriate episodes of laughing and crying and general emotional incontinence. Although many p...

    Authors: Fletcher Graham Young and Diep Nguyen

    Citation: Journal of Medical Case Reports 2020 14:235

    Content type: Case report

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  25. Gastric carcinoma (GC) with second primary malignancy (SPM) is the most frequent combination within the multiple primary malignancies (MPM) group. The presentation of a GC associated with a synchronized SPM in...

    Authors: J. A. Martín-Pérez, C. Torres-Silva, R. Tenorio-Arguelles, D. A. García-Corona, S. Silva-González, J. A. Dominguez-Rodriguez, I. De Alba-Cruz, J. F. Nagore-Ancona, J. A. González-Luna and K. A. López-Bochm

    Citation: Journal of Medical Case Reports 2020 14:234

    Content type: Case report

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  26. Transverse testicular ectopia (TTE) is a rare anomaly in which both testes descend through a single inguinal canal into the same hemiscrotum. Although almost 20–50% of patients with TTE exhibit persistent Müll...

    Authors: Takashi Nagai, Kentaro Mizuno, Masayuki Usami, Hidenori Nishio, Taiki Kato, Akihiro Nakane, Daisuke Matsumoto, Satoshi Kurokawa, Hideyuki Kamisawa, Tetsuji Maruyama, Takahiro Yasui and Yutaro Hayashi

    Citation: Journal of Medical Case Reports 2020 14:233

    Content type: Case report

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  27. BCR-ABL1, resulting from t(9;22), is the oncogenic driver of chronic myeloid leukemia and the therapeutic target of the disease. Molecular studies have been the gold standard modality for patient assessment si...

    Authors: Haider Ali Malakzai, Soma Rahmani, Ahmed Maseh Haidary, Sarah Noor, Maryam Ahmad, Abdul Sami Ibrahimkhil and Samuel Sharif

    Citation: Journal of Medical Case Reports 2020 14:231

    Content type: Case report

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  28. Immune checkpoint inhibitors have shown clinically significant antitumor efficacy and have been approved for the treatment of various kinds of advanced malignancies. On the other hand, these immunotherapies sh...

    Authors: Sachiyo Onishi, Masahiro Tajika, Hideaki Bando, Yuki Matsubara, Waki Hosoda, Kei Muro and Yasumasa Niwa

    Citation: Journal of Medical Case Reports 2020 14:230

    Content type: Case report

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  29. Neurogenic tumors of the larynx are rare, with few cases having been reported in the literature. Schwannomas are responsible for 0.1% of all benign tumors of the larynx. They arise in the sheaths of the periph...

    Authors: Claudiney Candido Costa, Hugo Valter Lisboa Ramos, Wilder Alves, Pauliana Lamounier, Leandro de Castro Velasco and Mikhael Romanholo El Cheikh

    Citation: Journal of Medical Case Reports 2020 14:229

    Content type: Case report

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  30. Osteosarcoma is a malignant tumor of the bone. The giant cell-rich osteosarcoma (GCRO) is a rare histological variant of the conventional osteosarcoma, accounting for 3% of all osteosarcomas. It has a variable...

    Authors: Laura Mosquera-Salas, Nathalia Salazar-Falla, Bladimir Perez, Saveria Sangiovanni, Luz F. Sua and Liliana Fernández-Trujillo

    Citation: Journal of Medical Case Reports 2020 14:228

    Content type: Case report

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  31. Primary malignant tumors of the aorta are extremely rare. They are frequently located in the abdominal aorta, followed by the thoracic aorta. Sarcomas are the most common histological type. These tumors origin...

    Authors: Liliana Fernández-Trujillo, Daisy C. Buenaventura and Luz F. Sua

    Citation: Journal of Medical Case Reports 2020 14:226

    Content type: Case report

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  32. Fever, as an adverse event, is well documented in a wide array of drugs including multiple tyrosine kinase inhibitors however, it is not a previously well described consequence of the novel multi-targeted tyro...

    Authors: H. M. N. Chen, M. Morris and P. M. Manders

    Citation: Journal of Medical Case Reports 2020 14:225

    Content type: Case report

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  33. Normal-tension glaucoma is known as a multifactorial optic neuropathy. A number of lines of evidence suggested that vascular factors played a significant role in the development of normal-tension glaucoma. The...

    Authors: Ali Nowrouzi, Javier Benitez-del-Castillo, Sepideh Kafi-abasabadi, Mario Rodriguez-Calzadilla, Antonio Diaz-Ramos, Alejo Rodriguez-Suarez and Inmaculada Mota-Chozas

    Citation: Journal of Medical Case Reports 2020 14:224

    Content type: Case report

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  34. The association between non seminomatous germ cell tumors (GCTs) and hematological malignancies of rare lineage has been described in the literature. In some of these cases there is evidence that the leukemia ...

    Authors: M. Spencer Chapman, P. C. May, E. Olavarria and E. Nadal Melsio

    Citation: Journal of Medical Case Reports 2020 14:222

    Content type: Case report

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  35. Choriocarcinoma is an aggressive malignancy of trophoblastic tissue, typically of gestational etiology. Sporadic, nongestational cases are rarely found outside of the gonads. There are only 31 cases of primary...

    Authors: Jessica Boyce, Karine Tawagi and John T. Cole

    Citation: Journal of Medical Case Reports 2020 14:220

    Content type: Case report

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  36. Intraoperative contralateral pneumothorax during one-lung ventilation is a rare but life-threatening complication. Although the exact incidence is unknown, only 14 cases with this complication have been report...

    Authors: Sakiko Kumata, Katsunari Matsuoka, Shinjiro Nagai, Mitsuhiro Ueda, Yoshinori Okada and Yoshihiro Miyamoto

    Citation: Journal of Medical Case Reports 2020 14:221

    Content type: Case report

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  37. Abdominal compartment syndrome (ACS) is defined as a sustained raised level of intra-abdominal pressure more than 20 mmHg with or without abdominal perfusion pressure less than 60 mmHg and the development of n...

    Authors: Daisuke Usuda, Kohei Takanaga, Ryusho Sangen, Toshihiro Higashikawa, Shinichi Kinami, Hitoshi Saito and Yuji Kasamaki

    Citation: Journal of Medical Case Reports 2020 14:219

    Content type: Case report

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  38. Facial baroparesis is a palsy of the seventh cranial nerve resulting from increased pressure compressing the nerve along its course through the middle ear cavity. It is a rare condition, most commonly reported...

    Authors: Jason P. Caffrey, Jason W. Adams, Isabel Costantino, Kristin Klepper, Elina Kari and Lori A. Brown

    Citation: Journal of Medical Case Reports 2020 14:218

    Content type: Case report

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  39. Hemophagocytic lymphohistiocytosis (HLH) is a rare heterogenous genetic or acquired hyperinflammatory syndrome associated with a high degree of morbidity and mortality. HLH has clinical manifestations related ...

    Authors: Linn Hereide Trovik, Miriam Sandnes, Bjørn Blomberg, Gunhild Holmaas, Aymen Bushra Ahmed, Tor Henrik Anderson Tvedt, Olav Vintermyr and Håkon Reikvam

    Citation: Journal of Medical Case Reports 2020 14:217

    Content type: Case report

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  40. Granulomatous mastitis (GM) is a rare benign chronic inflammatory breast disease. GM presents as a heterogeneous illness with variable clinical presentations, and its diagnosis is usually made by exclusion. Th...

    Authors: Richard Chalmers, Patrick McClellan, Vixey Silva, Natalie Shutt and Carolina Restini

    Citation: Journal of Medical Case Reports 2020 14:215

    Content type: Case report

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  41. Several recent studies suggest the possibility of a skin rash being a clinical presentation of coronavirus disease 2019 (COVID-19). The purpose of this case report is to bring attention to skin manifestations ...

    Authors: Alice Serafini, Peter Konstantin Kurotschka, Mariabeatrice Bertolani and Silvia Riccomi

    Citation: Journal of Medical Case Reports 2020 14:216

    Content type: Case report

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