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Table 1 Eight reported cases with pneumatosis cystoides intestinalis induced by α-glucosidase inhibitor administration for diabetes mellitus (modified from [10])

From: Pneumatosis cystoides intestinalis of the ascending colon related to acarbose treatment: a case report

Author Age, sex Diabetes mellitus + Concomitant drug α-GI, daily dose, duration Main symptoms Localization Prescription of α-GI+ after onset of PCI Outcome Treatment
Tsujimoto et al.[10] 69, M Myasthenia gravis Steroid SU Voglibose 0.6 mg 20 months Increased flatus, constipation, hematochezia Sigmoid colon Discontinuation Healing after 14 days Conservative
Hisamoto et al.[11] 56, F Intestinal pneumonitis Steroid Voglibose 0.6 mg 7 days Dyspnea, no abdominal symptoms Ascending colon Discontinuation Healing after 7 days Conservative
Maeda et al.[12] 72, F Nephrotic syndrome Insulin Steroid Immunosuppressant Voglibose 0.9 mg 3 years Abdominal pain, SIRS, DIC   Discontinuation Healing after 7 days Conservative
Saito et al. [13] 53, F Dermatomyositis Steroid Immunosuppressant Voglibose 0.6 mg 1 month Nausea, flatulence Ascending colon + descending colon Discontinuation Healing after 21 days Conservative
Yanaru et al.[14] 61, M Unknown SU Voglibose 0.6 mg 5 years Constipation, hematochezia Sigmoid colon Discontinuation Healing after 28 days Conservative
Azami [15] 87, F Hypothyroidism SU Acarbose 150 mg 1 year Paralytic ileus, abdominal distension Small intestine Discontinuation Healing after 5 days Conservative
Hayakawa et al.[16] 64, F Unknown Insulin Voglibose 0.6 mg 1 month Abdominal distention, flatulence Ascending colon + transverse colon Discontinuation Healing after 4 days Conservative
Furio et al.[17] 64, F Unknown Insulin Acarbose unknown 3 years Diarrhea, abdominal pain, weight loss Sigmoid colon ascending colon + descending colon caecum Discontinuation Healing after 15 days Conservative
Our patient 65, F Hypertension   Acarbose 150 mg 12 years Left abdominal pain Ascending colon Discontinuation Healing after 7 days Conservative
  1. Six additional cases published in the Japanese language were recently reviewed by Tsujimoto et al. [10]. α-GI, α-glucosidase inhibitor; M, male; F, female; SIRS, systemic inflammatory response syndrome; DIC, disseminated intravascular coagulation; SU, sulfanylurea.