Pneumatosis cystoides intestinalis of the ascending colon related to acarbose treatment: a case report

Vogel, Yilin; Buchner, Nikolaus J; Szpakowski, Michael; Tannapfel, Andrea; Henning, Bernhard F

doi:10.4076/1752-1947-3-9216

Journal of Medical Case Reports

Table 1 Eight reported cases with pneumatosis cystoides intestinalis induced by α-glucosidase inhibitor administration for diabetes mellitus (modified from [10])

From: Pneumatosis cystoides intestinalis of the ascending colon related to acarbose treatment: a case report

Author	Age, sex	Diabetes mellitus +	Concomitant drug	α-GI, daily dose, duration	Main symptoms	Localization	Prescription of α-GI+ after onset of PCI	Outcome	Treatment
Tsujimoto et al.[10]	69, M	Myasthenia gravis	Steroid SU	Voglibose 0.6 mg 20 months	Increased flatus, constipation, hematochezia	Sigmoid colon	Discontinuation	Healing after 14 days	Conservative
Hisamoto et al.[11]	56, F	Intestinal pneumonitis	Steroid	Voglibose 0.6 mg 7 days	Dyspnea, no abdominal symptoms	Ascending colon	Discontinuation	Healing after 7 days	Conservative
Maeda et al.[12]	72, F	Nephrotic syndrome	Insulin Steroid Immunosuppressant	Voglibose 0.9 mg 3 years	Abdominal pain, SIRS, DIC		Discontinuation	Healing after 7 days	Conservative
Saito et al. [13]	53, F	Dermatomyositis	Steroid Immunosuppressant	Voglibose 0.6 mg 1 month	Nausea, flatulence	Ascending colon + descending colon	Discontinuation	Healing after 21 days	Conservative
Yanaru et al.[14]	61, M	Unknown	SU	Voglibose 0.6 mg 5 years	Constipation, hematochezia	Sigmoid colon	Discontinuation	Healing after 28 days	Conservative
Azami [15]	87, F	Hypothyroidism	SU	Acarbose 150 mg 1 year	Paralytic ileus, abdominal distension	Small intestine	Discontinuation	Healing after 5 days	Conservative
Hayakawa et al.[16]	64, F	Unknown	Insulin	Voglibose 0.6 mg 1 month	Abdominal distention, flatulence	Ascending colon + transverse colon	Discontinuation	Healing after 4 days	Conservative
Furio et al.[17]	64, F	Unknown	Insulin	Acarbose unknown 3 years	Diarrhea, abdominal pain, weight loss	Sigmoid colon ascending colon + descending colon caecum	Discontinuation	Healing after 15 days	Conservative
Our patient	65, F	Hypertension		Acarbose 150 mg 12 years	Left abdominal pain	Ascending colon	Discontinuation	Healing after 7 days	Conservative

Six additional cases published in the Japanese language were recently reviewed by Tsujimoto et al. [10]. α-GI, α-glucosidase inhibitor; M, male; F, female; SIRS, systemic inflammatory response syndrome; DIC, disseminated intravascular coagulation; SU, sulfanylurea.

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ISSN: 1752-1947

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