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Table B Review of Systems

From: Morgellons disease, illuminating an undefined illness: a case series

Dermatologic 24% of patients had dark filaments visibly protruding from the skin‡1
17 out of 25 had frequent skin eruptions/rashes†
Just over 50% experienced no movement sensations†
Only 50% itched regularly†
72% has angiomata appear
Central Nervous System Over half had frequent headaches†
Over half had unstable visual acuity including double vision (10 out of 25)†
10 out of 25 reported visual “flashes” (not characterized) in either daylight or dark†
Emotional liability in half of patients 1/3 reported frequent dizziness
Metabolic Average weight gain after onset: 33 lbs†
2 20 out of 25 experienced regular high levels of fatigue†
  1/3 reported permanent hearing loss (degree not determined)
40% reported tinnitus
20 out of 25 reported frequent occurrence of forgetfulness
12 out of 25 had persistent regional skin numbness
6 out of 25 had persistent tremors
25% were intolerant to cold and 25% intolerant to heat (some overlap, but degree undetermined)
10 out of 25 reported sweating inappropriately (either under-or over-sweating)
Immune 12 out of 25 had cyclical fever†
18 out of 25 reported numerous angiomas verified by examination†
10 out of 25 reported many “colds” annually*
8 out of 25 reported “chronic sinusitis”*
4 out of 25 reported frequent sore throats over a period of years*
2 out of 25 reported frequent toothaches*
Endocrine 8 out of 25 had prior diagnosis of Hashimoto’s Thyroiditis
50% had hypercalcemia, 3 of whom had parathyroid adenomas
Fasting insulin levels were elevated in all tested (6 out of 25)
Corticotrophin Releasing Hormone (CRH) levels were elevated in all tested
Musculo-skeletal 15 out of 25 reported frequent neck pain†
10 out of 25 had persistent limited neck movement†
22 out of 25 had chronic musculoskeletal pain, without arthritis‡
Gastro-intestinal 50% had constipation or diarrhea, or both (overlap was common)†
25% had chronic nausea†
  Pain was constant and incapacitating in 1/3 of patients† Pulmonary Persistent cough (non-productive, non-wheezing) in 9 out of 25†
Persistent dyspnea in 7 out of 25
Emotional Half reported “anxiety”
Half reported frequent mood swings
Half reported frequent depression
Other Urine stream control problems in 6 out of 25
  1. 1 Less than half of the 25 patients studied reported the presence of filaments, and as a result, the authors did not search for filaments on all patients.
  2. 2 Average weight gain in male and female patients combined. Time period for weight gain undetermined.