Fig. 3

Metastatic invasive ductal carcinoma to the scalp. Hematoxylin and eosin stain of the tumor showing poorly formed glands filling the dermis with normal overlying epidermis (A), immunohistochemistry (IHC) for estrogen receptor (ER) showed that almost all tumor cell nuclei are estrogen receptor positive, highlighted by brown nuclear staining (B), IHC for GATA-3 illustrates the strong positive nuclear staining (brown) in all tumor cells (C), cytokeratin-7 IHC demonstrates positive membrane staining of the tumor cells (D), p63 IHC is negative in the tumor cell nuclei (lack of brown staining), whereas the nuclei of the overlying epidermis are positive (E), and IHC for CD117 is negative in the tumor cells, but shows reactivity in the melanocytes in the overlying epidermis (F). Original magnification of all pictures was × 200