Patient 1 | Patient 2 | |||
---|---|---|---|---|
At Peak1 | At 26 wks | At Peak2 | At 27 wks | |
Neurologic symptoms subscore (0–1300)*: | 898 | 4 | 810** | 235 |
Decreased mental alertness (0–100) | 62 | 0 | 80 | 0 |
Headache (0–100)** | 51 | 0 | ** | 0 |
Memory impairment (0–100) | 96 | 0 | 85 | 25 |
Confusion/odd behavior (0–100) | 61 | 0 | 80 | 25 |
Decreased executive function (0–100) | 100 | 0 | 100 | 60 |
Personality change (0–100) | 85 | 0 | 90 | 50 |
Emotional lability (0–100) | 75 | 0 | 85 | 20 |
Intellectual impairment | ||||
Affecting school/work (0–100) | 100 | 4 | 100 | 55 |
Paresthesias (0–100)** | 74 | 0 | ** | 0 |
Imbalance/ataxia (0–100) | 52 | 0 | 85 | 0 |
Difficulty walking (0–100) | 44 | 0 | 80 | 0 |
Bladder dysfunction (0–100) | 49 | 0 | 25 | 0 |
Apraxia (0–100)** | 49 | 0 | ** | 0 |
Inner ear symptoms subscore (0–500): | 49 | 0 | 0 | 90 |
Hearing loss on R (0–100) | 0 | 0 | 0 | 40 |
Hearing loss on L (0–100) | 0 | 0 | 0 | 50 |
Tinnitus R (0–100) | 0 | 0 | 0 | 0 |
Tinnitus L (0–100) | 0 | 0 | 0 | 0 |
Vertigo (0–100) | 49 | 0 | 0 | 0 |
Eye symptoms subscore (0–400): | 0 | 0 | 0 | 0 |
Visual disturbance on R (0–100) | 0 | 0 | 0 | 0 |
Visual disturbance on L (0–100) | 0 | 0 | 0 | 0 |
Visual field loss on R (0–100) | 0 | 0 | 0 | |
Visual field loss on L (0–100) | 0 | 0 | 0 | 0 |
Total symptoms score (0–2200): | 947 | 4 | 810** | 325 |
Global assessment of disease activity in: | ||||
Brain (0–100) | 71 | 0 | 100 | 0 |
Inner ear (0–100) | 33 | 0 | 0 | 0 |
Eyes (0–100) | 0 | 0 | 0 | 0 |