Table1 Pulmonary hemosiderosis complicated by Down syndrome reported in the literature
References | Age | Sex | Medical history | Other associated diseases | Signs of onset | Diagnosis confirmation | Treatment | Prognosis |
|---|---|---|---|---|---|---|---|---|
Aceti et al. [1] | 4 years 7 months | Female | Recurrent respiratory infections | Ventricular and atrial septal defect, Patent ductus arteriosus | - Cough, Hemoptysis | Chest radiography CT scan BAL | Corticosteroids Hydroxychloroquine | Relapse occurring in the following year |
Bakalli et al. [2] | 13 years | Female | Severe anemia | Idiopathic thrombocytopenic purpura | Pallor, Extreme tiredness, Dyspnea | Chest X-ray CT scan Gastric lavage fluid | Corticosteroids Azathioprine | No relapses |
Watanabe et al. [9] | 9 years | Female | Fatigability Cough Vomiting of blood sputum | Hypothyroidism Autism | Hypoxemia Suspected acute pneumonia | Chest X-ray, CT scan Bronchoscopy | Oxygen supply Corticosteroid Antibiotic | Relapse 2 weeks after discharge treated by prednisolone with good clinical response |
Alimi et al. [3] | 2.9 ± 3.45 years | Four girls and five boys | – | PH (three patients) Congenital cardiopathy (four patients) Positive antinuclear antibodies (six cases) | Hemoptysis (two cases) Cough (two cases) Dyspnea (nine cases) Pneumonia (three cases) | Chest radiography CT scan BAL | Corticosteroids Hydroxychloroquine (one case) Immunosuppressive drugs (mycophenolate mofetil, cyclophosphamide, and/or azathioprime; three cases) | Relapses (six cases) PH (five cases) Death (three cases) |