Table 1 Summary of tamoxifen-related macular hole case reports in the current literature
Author | Year of publication | Relevant history (age and cancer history) | Total tamoxifen given | Presenting symptoms | OCT findings |
|---|---|---|---|---|---|
Gualino et al. | 2005 | Case 1: 64-year-old woman with history of breast cancer status-post (s/p) mastectomy | 34.2 g | N/A | Foveolar cystoid space with focal disruption of the photoreceptor line OU |
Case 2: 72-year-old woman with history of breast cancer | 30.6 g | N/A | Foveolar cystoid space with focal disruption of photoreceptor line in OD, with no macular thickening | ||
Chung et al. | 2010 | 51-year-old woman s/p radical mastectomy for invasive ductal breast cancer 7 years prior | 0.9 g | Decreased visual acuity | Focal defect of outer retinal layer in the fovea OS Normal OD |
Caramoy et al. | 2011 | 49-year-old woman with history of breast cancer s/p mastectomy 6 years prior | 33 g | 11 months of visual acuity deterioration, central scotoma in OS | Defect in the outer retinal layer with sharp edges; posterior hyaloid still attached |
Georgalas et al. | 2013 | 55-year-old woman with history of breast cancer, diagnosed 11 years prior | 73 g | Gradual visual deterioration OU | Extensive areas of disruption in inner retinal layers OU |
Doshi et al. | 2014 | Case 1: 63-year-old woman with hx of stage 1 breast cancer s/p mastectomy 14 years prior | 36.5 g | Difficulty with reading | Cavitary spaces with disruption of the outer retinal bands OS > OD |
Case 2: 50-year-old woman with history of breast cancer s/p lumpectomy and radiation 3 years prior | 18.25 g | Distortion in OS for 1 year | Thinning of inner retina with draping of ILM OD and near full-thickness cavitation OS | ||
Case 3: 52-year-old woman with history of breast cancer s/p bilateral mastectomy with chemotherapy and radiation 8 years prior | 58.4 g | Blurred vision and central scotoma OS for 1 year | Cavitary space OS | ||
Hu et al. | 2016 | 53-year-old woman with history of ductal breast carcinoma s/p radical mastectomy and adjuvant chemotherapy 3 years prior | 18 g | Gradual decrease of visual acuity OU for 3 months | Ruptured ellipsoid zone, granular change of outer segments of photoreceptors in OD Macular hole in OS |
Torrell-Belzach et al. | 2020 | 63-year-old woman with history of breast cancer diagnosed at age 41 | 73 g | Mild, progressive bilateral vision loss for years | Bilateral macular hole with a thin overlying roof of inner retinal remnant and small cystic spaces in the periphery of the hole Posterior hyaloid attached |