Table 1 Biological characteristics of the reported case at the time of onset of nivolumab-induced isolated adrenocorticotrophic hormone deficiency
Hormone | Patient’s value | Normal range |
|---|---|---|
Morning AdrenoCorticoTropic Hormone (ACTH) | 5.8 ng/L | 8:00 am: 7.2–63 ng/L |
Morning cortisol | 26 nmol/L | 8:00 am: 166–507 nmol/L |
TSH | 2.89 mU/L | 0.3–4.20 mU/L |
Free Tetraiodothyronine (fT4) | 18.8 pmol/L | 9.3–23.2 pmol/L |
Free Triiodothyronine (fT3) | 3.8 pmol/L | 3.1–6.8 pmol/L |
Luteinic Hormone (LH) | 6.0 U/L | 1.7–8.6 U/L |
Follicular Stimulating Hormone (FSH) | 8.4 U/L | 1.5–12.4 U/L |
Testosterone | 17.8 ng/L | 6.68–27.7 ng/L |
C-Reactive Protein (CRP) | 2.6 mg/L | < 5.0 mg/L |
Fasting blood sugar | 66 mg/dL | 70–100 mg/dL |
Insulin Growth factor-1 (IGF-1) | 127 ng/mL | 26–245 ng/mL |
Growth hormone | 16.7 mcg/L | 12–22.0 mcg/L |
Sodium | 140 mmol/L | 135–145 mmol/L |
Urea | 23.6 mg/dL | 16.6–48.5 mg/dL |
Serum creatinine | 0.88 mg/dL | 0.70–1.20 mg/dL |
Total leukocytes | 8.8 G/L | 3.5–11.0 G/L |
Neutrophil count | 4.09 G/L | 1.7–6.7 G/L |
Lymphocytes count | 3.68 G/L | 1.2–3.5 G/L |
Hemoglobin level | 14.4 g/dL | 13–18 g/dL |
Platelet count | 341 G/L | 150–440 G/L |
Alanine aminotransferase (GPT) | 23 UI/L | < 41 UI/L |
Aspartate aminotransferase (GOT) | 18 UI/L | < 40 UI/L |
Alkaline phosphatase | 39 UI/L | 40–129 UI/L |
Gamma glutamyl transferase (GGT) | 24 UI/L | 10–71 UI/L |
Urinalysis | ||
Protein | Negative | Negative |
Blood | Negative | Negative |
Density | 1.020 | 1.005–1.020 |
pH | 6 | 4.5–6.5 |