Fig. 2From: Methotrexate-induced acute cardiotoxicity requiring veno-arterial extracorporeal membrane oxygenation support: a case reportHistopathology demonstrating myocardial necrosis. Myocardial cells with H and E stain demonstrate loss of nuclei with only one barely visible nucleus remnant in the center. FH dihydrofolate, dTMP thymidylate, dUMP deoxyuridine monophosphate. Image by Mikael Häggström, MD, used with permission. https://commons.wikimedia.org/w/index.php?curid=109899804Back to article page