Iatrogenic Kaposi sarcoma of the small bowel in Crohn’s disease following short-term use of immunomodulators: a case report and review of the literature

Table 1 Intestinal Kaposi sarcoma in HIV-negative patients with Crohn’s disease in the literature

First author, reported year, and journal	Age (years)/sex	Immunomodulators for Crohn’s disease	Duration of developed KS after immunomodulators	KS location	Skin lesions	HHV-8 status	Treatment of KS
Koop, 1987	29/F	Prednisone	Long-standing	Jejunum, bowel mesentery	Yes	NA	Small bowel resection
Am J Med	29/F	Prednisone	Long-standing	Jejunum, bowel mesentery	Yes	NA	Small bowel resection
Puy-Montbrun, 1991	36/F	Steroids	54 months	Colon	No	NA	Immunomodulators withdrawal
Dig Dis Sci	36/F	Azathioprine	11 months	Colon	No	NA	Immunomodulators withdrawal
Cohen, 2001	67/F	Prednisone	Long-standing	Ileum, colon	No	NA	Ileocolic resection
Am J Gastroenterol	67/F	Prednisone	Long-standing	Ileum, colon	No	NA	Ileocolic resection
Annika, 2017	21/M	Prednisone	Long-standing	Terminal ileum	No	Negative	Immunomodulators withdrawal
Int. J. Surg. Pathol	21/M	Infliximab	3 doses	Terminal ileum	No	Negative	Immunomodulators withdrawal
Elisa Stasi, 2019	45/F	Steroids	First 3 months	Terminal ileum	NA	Positive	Ileocecal resection
Medicine	45/F	Infliximab	9 months after administration	Terminal ileum	NA	Positive	Ileocecal resection
Present case	46/M	Prednisone	3 months	Small bowel	No	Positive	Chemotherapy
Present case	46/M	Azathioprine	4 months	Small bowel	No	Positive	Chemotherapy

F female, HIV human immunodeficiency virus, HHV-8 human herpesvirus-8, M male, NA no available data, KS Kaposi sarcoma

ISSN: 1752-1947