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Table 1 Patient demographics and clinical characteristics

From: Gross hematuria can be an impact of severe acute respiratory syndrome coronavirus 2 vaccination on immunoglobulin A nephropathy: a case report

Patient

Age (years)

Sex

Race

MH

Medications

Vaccine

Episodes of gross hematuria before vaccination

Baseline (hematuria/uPCR/sCr)

Timing of gross hematuria after vaccination

Associated symptoms

Presentation after second dose (hematuria/uPCR/sCr)

Follow-up after second dose (hematuria/uPCR/sCr)

Reference

1

38

F

W

IgAN

RAASi

Moderna

Yes

(positive/0.63/well-preserved kidney function)

D1 after the second dose

Fever at D1

NA

(NA/1.40/well-preserved kidney function) 3 weeks after

4

2

38

F

W

IgAN

CY + Pred, then RAASi

Moderna

No

(positive/0.63/well-preserved kidney function)

D1 after second dose

Fever at D1

NA

(NA/0.40/well-preserved kidney function) 3 weeks after

4

3

52

F

A

IgAN

RAASi

Pfizer

Yes

(NA/0.6331/0.7–0.8)

D1 after second dose

Fever

(positive/2.4113/NA)

(resolved/1.441/NA) 5 days after

5

4

41

F

C

DM

NA

Pfizer

No

(NA/neg/NA)

D2 after second dose

Generalized myalgia at D2

(> 200/1.73/2.03)

 

6

5

30

M

WE/SA

None

None

Moderna

No

NA

D2 after second dose

Fever at D2

(3+/4+/1.02)

(positive/0.08/NA) 2 weeks after

7

6

NA

NA

NA

IgAN

NA

Pfizer

Yes

(NA/1.56/0.8)

D6 after second dose

Myalgia at D6

(positive/3.0/3.53)

(NA/baseline/baseline) 2 months after

11

7

NA

NA

NA

IgAN

NA

Pfizer

No

(NA/0.61/1.0)

D1 after second dose

Body aches

(positive/0.92/1.16)

(resolved/NA/NA) 5 days after

11

8

41

F

NA

IgAN

Tac, MPA, and steroids for KT

Pfizer

NA

(NA/0/NA)

D1 after first dose

Marked leukocytosis

NA

(NA/0.41/GFR 57 ml/min/1.73 m2)

12

9

50

M

NA

IgAN, HTN

None

Pfizer

NA

(11–25/2.40/1/17)

D2 after second dose

NA

(> 50/3.56/1.54)

(11–25/2.20/1.24)

13

Our case

21

F

Japanese

None

None

Pfizer

No

(3+/negative/0.60)

D2 after second dose

Fever at D2

(> 100/0.15/0.57)

(10–19/0.09/0.56) 6 weeks after

 
  1. F female, W white, A Asian, C Chinese, M Malay, WE/SA Western European and South American, IgAN IgA nephropathy, DM diabetes mellitus, HL hyperlipidemia, HTN hypertension, MH medical history, RAASi renin–angiotensin–aldosterone system inhibitor, CY cyclophosphamide, Pred prednisone, Tac tacrolimus, MPA mycophenolic acid, KT kidney transplantation, sCr serum creatinine (in mg/dL), uPCR urinary protein-to-creatinine ratio (in g/g), NA not applicable. Hematuria is expressed as the number of red blood cells per high-power field or qualitative score (1+, mild; 2+, moderate; 3+, severe) on urinalysis. Proteinuria is also expressed as a qualitative score (1+, mild; 2+, moderate; 3+, severe; and 4+, very severe) on urinalysis. None of the patients had episodes of gross hematuria before vaccination, and none was known to have been infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), although neither serological nor polymerase chain reaction (PCR) testing was performed before and after vaccination