Fig. 2From: Tumor lysis syndrome following ifosfamide monotherapy in metastatic osteosarcoma: a case report and review of the literaturea–e Right lower-extremity biopsy microscopy showing hematoxylin and eosin (H&E) staining at 4× (a), 10× (b), and 20× (c) magnification showing malignant spindle cell proliferation with areas of osteoid deposition (arrows) all consistent with osteosarcoma. d 10× magnification showing negative Ck AE1/AE3 stains, ruling out carcinoma. e 10× magnification showing positive vimentin staining highlights the spindle cell portion of the tumor, demonstrating their mesenchymal originBack to article page