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Table 2 Thrombophilia and thrombocytopenia screening

From: Transjugular intrahepatic portosystemic shunt, local thrombaspiration, and lysis for management of fulminant portomesenteric thrombosis and atraumatic splenic rupture due to vector-vaccine-induced thrombotic thrombocytopenia: a case report

Test

Result

Normal range

aPTT (lupus sensitive)

25.2 seconds

25.1–36.5 seconds

Lupus anticoagulant (dRVVT)

Negative

–

Cardiolipin antibodies (IgG, IgM)

Negative

–

Antiphospholipid antibodies

Negative

–

β2-Glycoprotein antibodies (IgG, IgM)

Negative

–

Homocysteine

13.6 ÎĽmol/l

0–15 μmol/l

Factor VIII

120%

50–150%

APC resistance

Negative

–

Protein C activity

53%

70–140%

Factor V Leiden mutation (G1691G wild type)

Negative

–

Prothrombin mutation (G20210A wild type)

Negative

–

Haptoglobin

232 mg/dl

20–200 mg/dl

Paroxysmal nocturnal hemoglobinuria

Negative

–

ADAMTS-13 activity

67%

50–150%

C3 complement (g/l)

0.28

0.9–1.8

C4 complement (g/l)

0.05

0.1–0.4

Fragmentocytes

< 1%

< 1%

Rapid HIT assay

Negative

–

IgG-specific ELISA (PF4 antibodies)

Positive

–

HIPA (PF4/heparin; HIT type II)

Negative

–

PIPA (PF4-induced platelet aggregation/VITT)

Positive

–

  1. aPTT Activated partial thromboplastin time; dRVVT Dilute Russell's viper venom time; IgG Immunoglobulin G; IgM Immunogobulin M; APC-resistance Activated protein C resistance; ADAMTS-13 A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; C3 Complement component; C4 Complement component 4; HIT Heparin induced thrombocytopenia; ELISA Enzyme-linked immunosorbent assay; PF4 Platelet factor 4; HIPA Heparin-induced platelet aggregation assay; PIPA Platelet factor 4-induced platelet activation; VITT Vaccine-induced immune thrombotic thrombocytopenia