Genetic prescreening of a candidate for laser refractive surgery identifies risk for inadequate tissue response: a case report

Table 1 Variants found in the patient’s and his children’s deoxyribonucleic acid

	Chr	Position	Ref. allele	Allele 1	Allele 2	Gene	dbSNP	Protein/amino acid	PolyPhen2 prediction HumDiv	LRT prediction	PROVEAN prediction
Father	5	90079091	A	A	G	ADGRV1	rs182698253	p.H4461R	Probably damaging	Deleterious	Damaging
	8	141771274	T	T	C	PTK2	N/A	p.Y526C	N/A	N/A	N/A
	16	88504716	G	G	T	ZNF469	rs568704426	p.G3585V	Benign	N/A	Neutral
	17	39674737	G	G	A	KRT15	rs201164162	p.R115C	Probably damaging	Deleterious	Damaging
Daughter	17	39674737	G	G	A	KRT15	rs201164162	p.R115C	Probably damaging	Deleterious	Damaging
Son	5	90079091	A	A	G	ADGRV1	rs182698253	p.H4461R	Probably damaging	Deleterious	Damaging
	16	88504716	G	G	T	ZNF469	rs568704426	p.G3585V	Benign	N/A	Neutral
	17	39674737	G	G	A	KRT15	rs201164162	p.R115C	Probably damaging	Deleterious	Damaging

ISSN: 1752-1947