Fig. 2

Diagnostic process. A Blood smear of the index patient showing bite cells (black arrow head) and basophilic stippling (blank arrow head). B High-performance liquid chromatography (HPLC) of the index patient showing the values for HbA2, HbF, and variant hemoglobin (red arrow), with the same retention time as for HbA1c (0.693 minutes) in HPLC. C Capillary electrophoresis of the index patient showing two peaks for HbF and an abnormal peak for HbA (adult hemoglobin). These findings are consistent with a high suspicion of a variant hemoglobin