Table 1 Treatment-related toxicities (common terminology criteria for adverse events grade 2–4) during intensive chemotherapy treatment (Acute Lymphoblastic Leukemia Intercontinental Berlin–Frankfurt–Münster 2009)

Infections and infestations

 Sepsis

Consolidation

4

Citrobacter

 Invasive fungal infections

None

N/A

Blood and lymphatic system disorders

 Febrile neutropenia

Induction, consolidation, re-induction

3

 Anemia

Induction, consolidation, re-induction

3

 Platelet count decreased

Induction, consolidation, re-induction

3–4

 Coagulation disorders (fibrinogen decreased)

Induction, consolidation, re-induction

2–3

Gastrointestinal disorders

 Mucositis

Induction, consolidation

3

 Pancreatitis

None

N/A

Hepatobiliary disorders

 Transaminitis (ALT, AST increased)

Consolidation, re-induction

3

 Blood bilirubin increased

Early intensification

2

 GGT increased

Early intensification, consolidation, re-induction

3

3–4

Metabolism and nutrition disorders

 Hyperglycemia

Induction, consolidation, re-induction

3

Steroid-induced

 Anorexia (malnutrition)

Induction, consolidation

2–3

Clinically grade 2, laboratory and neuroradiology results indicate a higher grade

 Iron overload

Re-induction

2

Endocrine disorders

 Adrenal insufficiency

Induction, consolidation, re-induction

2–3

 Hypothyroidism

Induction

2

Vascular disorders

 Hypertension

Induction, ongoing

3

 Thromboembolic events

None

N/A

Renal and urinary disorders

 Chronic kidney disease

Consolidation

2

Underlying condition

 Acute kidney disease

Early intensification

3

Amfotericin B-induced

Nervous system disorders

 Polineuropathy

Induction, ongoing

3

 Convulsions

Re-induction

2

Psychiatric disorders

 Psychosis

Re-induction

3–4

Steroid-induced

Immune system disorders

 Allergic reactions

None

N/A

Musculoskeletal and connective tissue disorders

 Avascular necrosis

None

N/A

 Osteoporosis

Re-induction

2

Skin and subcutaneous tissue disorders

 Dermatitis

Re-induction

2–3

Steroid-induced