Fig. 2
From: Severe thyrotoxicosis as initial presentation of gastric choriocarcinoma: a case report
Histopathology biopsy results. Upper-left image: The microscopic field shows the morphologic features of the neoplasm with a biphasic growth pattern with pleomorphic multinucleated cells (blue circle) surrounding islands of basophilic, mononucleated cells (black circle) in a lacunar vascular pattern. (Hematoxylin & eosin, 100×). The other images show the tumor immunoprofile: GATA3+, hCG+, hPL, and PLAP focally positive, supporting the diagnosis of choriocarcinoma. Neoplastic cells had strong and diffuse membranous reactivity to PD-L1 antibody, as normal placental villous tissue does (inset)