Table 2 Revised Sapporo classification criteria for antiphospholipid antibody syndrome (APS) [8]
APS is present if at least one clinical and one laboratory criterion is met: | |
|---|---|
Clinical criteria | Laboratory criteria |
1. Vascular thrombosis | 1. Lupus anticoagulant (LA)a |
≥ 1 clinical episode of arterial, venous or small vessel thrombosis in any tissue or organ | Present in plasma, on ≥ 2 occasions at least 12 weeks apart |
2. Pregnancy morbidity | 2. Anti-cardiolipin (aCL) antibody |
≥ 1 unexplained death of a morphologically normal fetus at or beyond the 10th week of gestation with normal fetal morphology documented by ultrasound or direct examination | IgG and/or IgM isotype in serum or plasma, present at medium or high titer, on ≥ 2 occasions at least 12 weeks apart |
≥ 1 premature birth of a morphologically normal neonate before the 34th week of gestation due to eclampsia or severe preeclampsia or placental insufficiency | 3. Anti-β2-glycoprotein-I antibody |
IgG and/or IgM isotype in serum or plasma on ≥ 2 occasions at least 12 weeks apart | |
≥ 3 unexplained consecutive spontaneous abortions before the 10th week of gestation | |