Table 2 Naranjo algorithm—adverse drug reaction probability scale
From: Oxaliplatin-induced thrombotic microangiopathy: a case report
Question | Yes | No | Do not know | Score |
|---|---|---|---|---|
1. Are there previous conclusive reports on this reaction? [12,13,14,15,16,17,18] | +1 | 0 | 0 | +1 |
2. Did the adverse event appear after the suspected drug was administered? | +2 | −1 | 0 | +2 |
3. Did the adverse event improve when the drug was discontinued or a specific antagonist was administered? | +1 | 0 | 0 | +1 |
4. Did the adverse event reappear when the drug was readministered? | +2 | −1 | 0 | 0 |
5. Are there alternative causes that could on their own have caused the reaction? | −1 | +2 | 0 | +2 |
6. Did the reaction reappear when a placebo was given? | −1 | +1 | 0 | 0 |
7. Was the drug detected in blood or other fluids in concentrations known to be toxic? | +1 | 0 | 0 | 0 |
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased? | +1 | 0 | 0 | 0 |
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | +1 | 0 | 0 | 0 |
10. Was the adverse event confirmed by any objective evidence? | +1 | 0 | 0 | 0 |
Total score: 6 | ||||