From: Oxaliplatin-induced thrombotic microangiopathy: a case report
Timepoint | Pre-chemotherapy | Day 1 (ED) | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | Day 9 | Day 10 | Day 11 | Day 12 | Day 13 | Day 14 | Day 15 | Day 22 | Day 27 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adjusted WBCs (per mm3) | 11,000 | 9800 | 6337 | 3900 | 2574 | 4600 | 6400 | 7000 | 7100 | 7900 | 6600 | 6400 | 6400 | 5600 | 4800 | 4700 | 4900 | 7000 |
Hemoglobin (g/dL) | 11.1 | 8.9 | 8.1 | 7.9 | 8.1 | 7.5 | 8.6 | 7.8 | 8.4 | 7.8 | 6.7 | 9.5 | 10.4 | 9.8 | 9.8 | 9.5 | 8 | 9.1 |
Platelets (×103/mm3) | 301 | 33.8 | 30 | 10 | 7.5 | 13.1 | 39.4 | 78.8 | 91.9 | 61 | 69 | 80 | 104 | 117 | 121 | 134 | 121 | 116 |
Creatinine (mg/dL) | 0.9 | 5.5 | 5.8 | 4.9 | 3.7 | 3.1 | 3 | 2.9 | 4.3 | 3.1 | 3.1 | 3.1 | 3.9 | 3.9 | 3.2 | 2.6 | 1.2 | 1.1 |
Total/direct bilirubin (mg/dL) | 0.4/0.1 | 3.3/2.2 | 1.8/1 | 1.4/0.6 | 1.1/0.4 | 0.8/0.3 | 0.6/0.2 | 0.7/0.3 | 0.5/0.2 | |||||||||
AST (IU/L) | 26 | 1725 | 347 | 83 | 38 | 38 | ||||||||||||
ALT (IU/L) | 19 | 930 | 294 | 99 | 49 | 39 | ||||||||||||
Haptoglobin (g/L) | < 0.1 | 0.52 | 0.22 | 0.49 | 0.59 | 0.55 | 0.68 | 0.6 | 0.54 | 0.69 | 0.82 | 0.94 | 0.94 | 1.31 | ||||
LDH (IU/L) | 237 | 4866 | 1093 | 429 | 265 | 283 | 297 | 266 | 266 | 249 | 224 | 219 | 231 | 221 | 161 | 148 | 159 |