Fig. 5

Structure and mutations of ApoE. A Important regions of ApoE and the difference among E2, E3, and E4 at positions 112 and 158. B Seventeen different ApoE mutations reported, and a novel mutation, ApoE Ganzhou (Arg43Cys), marked in red. LRBS LDL-receptor binding site, HR hinge region, LBP lipid binding position, Cys cysteine, Arg arginine, Glu glutamic acid, Lys lysine, Pro proline, Gly glycine, Leu leucine, Ser serine, del deletion, Ala alanine, Gln glutamine, Asp aspartic acid, Tyr tyrosine