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Fig. 3 | Journal of Medical Case Reports

Fig. 3

From: A novel homozygous missense variant p.D339N in the PKLR gene correlates with pyruvate kinase deficiency in a Pakistani family: a case report

Fig. 3

Three dimensional (3D) modeling of the PKLR protein structure. a Wild PK tetramer with the ligand and b closer view of the phosphoenolpyruvate site in the complex. c showing the interactions of wild PK with phosphoenolpyruvate through Arg116, Glu316, and Asp339, and d mutant PK and phosphoenolpyruvate interactions through Arg216 and Glu347

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Journal of Medical Case Reports

ISSN: 1752-1947