Table 2 Clinical and pathological findings in 7 cases of MTX-LPD occurring in the breast in RA
No. | Age/Sex | History of RA | Duration of MTX | Other RA treatment | Mass location | Pathology | EBV | Therapy and response | Follow up period | References |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 69/F | 24 years | 17 years | Etanercept (7 years) | Breast Lung Retroperitoneum | DLBCL | (−) | W + C→PR | 3.5 months | Pattanaik et al. [4] |
2 | 76/F | – | 7 months | – | Breast | DLBCL | (−) | W + C | – | Hashimoto et al. [5] |
3 | 63/F | 20 years | 10 years | – | Breast Subcutis | DLBCL | – | W→CR | 1 year | Fujimitsu et al. [6] |
4 | 79/F | 14 years | 2 years | Infliximab (2 years) | Bilateral breast Lymph nodes Subcutis | small B-cell lymphoma (marginal zone lymphoma) | – | W + C→CR | – | Costa et al. [7] |
5 | 67/F | – | – | – | NAC of the breast | DLBCL | – | W→PD→C→PR | 3 months | Matsubayashi et al. [8] |
6 | 77/F | 17 years | 13 years | – | Breast Lymph nodes | DLBCL | (−) | W→SD→C→CR | 16 months | Miyake et al. [9] |
7 | 63/F | 37 years | More than 15 years | – | Breast Subcutis Lung Retroperitoneum | DLBCL | (+) | W→CR | 1 year | Current case report |