Fig. 2

Histopathology of the uveal tumor. A, B Histopathological sections show a mushroom-shaped tumoral process (arrow) arising from retina composed of highly pleomorphic plump spindle cells with some dense melanin pigments in the background. Individual cells show high degree of nuclear atypia with prominent nucleoli. Tumor infiltrating lymphocyte and macrophage is less than 5%. Vessels show loop pattern (×40, ×100 H&E). C, D Immunohistochemical staining of the tumor shows diffuse, strong immunoreactivity for Melan-A and HMB-45 (×100, ×100)