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Fig. 1 | Journal of Medical Case Reports

Fig. 1

From: A farewell to phlebotomy—use of placenta-derived drugs Laennec and Porcine for improving hereditary hemochromatosis without phlebotomy: a case report

Fig. 1

Laennec induces the expression of hepcidin mRNA in both rat primary hepatocytes and HepG2 cells. a The possibility of inducing hepcidin through the administration of Laennec was examined using rat primary hepatocytes and HepG2 cells as target cells in vitro. Laennec induces the expression of hepcidin mRNA both in rat primary hepatocytes and HepG2 cells in a dose-dependent manner. Results are expressed as mean ± SD (**p < 0.01 versus 0 mg/mL Laennec). b Dose dependency in inducing the expression of Hamp by treatment with Laennec in iron-rich environment in HepG2. In the iron-rich environment, although the magnitude of response in inducing hepcidin secretion is relatively attenuated, hepcidin mRNA secretion is also observed in a dose-dependent manner. Results are expressed as mean ± SD (*p < 0.05, **p < 0.01 versus 0 µM FeSO4; ††p < 0.01 versus 0 mg/mL Laennec

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