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Table 1 Characteristics of newly diagnosed tuberculosis patients with a multiyear history of diabetes and a recent history of COVID-19

From: COVID-19 and chronic diabetes: the perfect storm for reactivation tuberculosis?: a case series

 

TR-241

TR-243

TR-247

Demographicsa

 Age in years, Sex

43, male

44, male

49, female

COVID-19 history

 Timing prior to TB diagnosis

3 months

6 months

4 months

 Anti-SARS-CoV-2 IgG at TB diagnosisb

Positive

Positive

Positive

 Symptoms at the time of the COVID-19 episode:

  Cough

Yes

Yes

Yes

  Fever, chills

Yes

Yes

Yes

  Fatigue

Yes

Yes

Yes

  Loss of smell and taste

Yes

Yes

Yes

  Shortness of breath

Yes

No

No

  Body aches

Yes

Yes

No

Duration of TB signs and symptoms prior to reporting to the TB clinic (days)

 Cough

90

180

120

 Productive cough

60

90

60

 Fever, chills

14

15

14

 Chest pain

3

N/R

N/R

 Weight loss

60

60

60

 Fatigue

N/R

N/R

30

TB diagnosis

 Acid-fast bacilli smear grade (bacilli/field)

> 10

> 10

> 10

 M. tuberculosis culturec

Positive

Positive

Positive

TB risk factors and other medical conditions

 Body mass index

13.4

23.7

29

 BCG vaccine

Yes

Yes

Yes

 HIV

Negative

Negative

Negative

 Smoking

No

No

No

 Alcohol excess and illicit drugsd

No

Yes

No

 Type 2 diabetes

Yes

Yes

Yes

  Years with type 2 diabetes

13 y

5 y

6 y

  HbA1c

8.2%

7.5%

10.6%

  Fasting blood glucose (mg/dl)

105

138

126

  Diabetes medicationse

Metformin

No

Glibenclamide metformin

 Other medical conditions

Peripheral neuropathy

None

High blood pressure

History of past TB or TB exposure

 Self-reported past exposure to a TB patient

No

No

Yes, > 2 years ago

 Prior testing for latent TB infection

No

No

No

 Past history of active TB

No

No

No

  1. N/R symptom not reported, TB tuberculosis, SARS-CoV-2 SARS coronavirus 2, COVID-19 coronavirus disease 2019, HIV Human immunodeficiency virus, HbA1c hemoglobin A1c
  2. aAll are Hispanic, White
  3. bAnti-SARS-CoV-2 IgG assay, Abbott Laboratories, Abbott Park, IL
  4. cM. tuberculosis spp. identified with BioLine MPT64 Rapid, Standard Diagnostics, Korea
  5. dTR-243: > 10 drinks and cocaine on weekends
  6. eTR-247: metformin 1700 mg/d; TR-249: Metformin 500 mg/d and glibenclamide 2.5 mg/day