Fig. 2
From: Two different presentations of de novo variants of CSNK2B: two case reports
Hypothetical association among the patients’ phenotypes to the CSK2B variants. In A, the Ribbon diagram illustrates the high-resolution structure of tetrameric CK2 and the location of the variants. p.His165Arg is located in close interaction between CK2β1 and CK2β2 and p.Asp32Tyr to the alfa1 catalytic subunit. In the crystal structure of full-length symmetric CK2 (α2β2) holoenzyme (PDB ID: 4MD7) (B), the β subunit interacts with different systems. Gray boxes contain previously described roles of CK2 and white boxes detail the putative association with the clinical manifestation of the reported patients.