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Table 1 Patient’s biochemical profile at admission to our unit, after therapy adjustments and at the last follow-up visit

From: Shrinkage of a pituitary metastasis of melanoma induced by pembrolizumab: a case report

Parameters and units

Admission values (26 June 2018)

First follow-up visit (26 July 2018)

Last follow-up visit (24 June 2020)

Normal values

Prolactin (µIU/ml)

482

410.63

86–324

FSH (mIU/ml)

1.2

1.5–12.4

LH (mIU/ml)

0.3

1.7–8.6

Total testosterone (ng/dl)

2.50

193–386

IGF-1 (ng/ml)

36.34

47–141

Cortisol (µg/dl)

18.52

21.40

13.5

7–32

UFC (µg/24 hours)

428.06

274.60

30–350

FT4 (pmol/L)

10.30

15.60

12.61

12.0–22.0

TSH (µIU/ml)

0.033

0.023

0.02

0.27–4.2

  1. Routine parameters were in the normal range (not reported), except for total cholesterol (236 mg/dl, normal range 130–220 mg/dl), while hormone assays demonstrated panhypopituitarism with hyperprolactinemia due to pituitary stalk compression. Replacement therapy with cortisone acetate (one and a half tablets per day) resulted in overdose, while levothyroxine (25 µg per day) was insufficient to reach normal FT4 levels (italics).
  2. FSH follicle-stimulating hormone, FT4 free thyroxine, IGF-1 insulin-like growth factor 1, LH luteinizing hormone, TSH thyroid-stimulating hormone, UFC urinary free cortisol.