Table 1 Clinical and laboratory features of the B-ALL case
Features | Case |
|---|---|
Age (years)/gender | 8/male |
Symptoms/lymphadenopathy and organomegaly | Hemorrhagic syndrome with multiple ecchymoses stretching on all four limbs and the face with petechiae/absent |
Complete blood cell count (CBC) data | |
Hemoglobin | 10 g/dl |
WBC | 20.3 × 109/L |
Platelets | 18 × 109/L |
Peripheral blood smears examination | Showed significant number of blasts: 25% |
Bone marrow examination data | |
% of blasts | 72% |
Cytochemical MPO | Negative |
Immunophenotypic data | |
% of blasts | 70% |
Expression of antigens | |
CD34 | 90% |
HLA-DR | 79% |
CD13 | 0% |
CD33 | 2% |
MPO | 1% |
CD19 | 97% |
CD10 | 97% |
CD22 | 67% |
CD79a | 8% |
IgMc | 0% |
cCD3 | 0% |
sCD3 | 0% |
CD7 | 0% |
Conventional cytogenetics | Did not reveal any clonal chromosomal abnormalities |
Cytogenetic study: fluorescence in situ hybridization (FISH) | Intrachromosomal amplification of chromosome 21 (iAMP21) |