Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report

Table 2 Genetic variants

Gene	Transcript	Transcript variant	Protein variant	SIFT prediction	PolyPhen-2 prediction	CADD	MSC-CADD	GDI	GDI prediction	dbSNP ID	gnomAD frequency
STAT1	NM_007315.4	c.1371G>A	p.V457V	NA	NA	15.03	7.736	0.73972	Medium	144704615	0.028
PSMD2	NM_001278709.2	c.679G>A	p.G227S	Tolerated	Probably damaging	26	6.072	4.97534	Medium	NA	0.000
CFI	NM_000204.5	c.1019T>C	p.1340T	Damaging	Possibly damaging	22.3	0.001	2.21508	Medium	769419740	0.007
PCDH18	NM_019035.5	c.3154G>A	p.G1052R	Damaging	Possibly damaging	23.7	3.313	2.92063	Medium	148983038	0.002
SNX9	NM_016224.5	c.199C>G	p.Q67E	Tolerated	Benign	16.55	3.313	2.29269	Medium	749203434	0.002
DOCKS	NM_001190458.2	c.499C>G	p.Q167E	Tolerated	Benign	18.27	0.001	18.28926	High	1233535978	0.000
GAS6	NM_000820.4	c,451C>T	p.R151W	Damaging	Probably damaging	32	3.313	3.51157	Medium	202152067	0.004
FANCI	NM_018193.3	c.2017C>T	p.H673Y	Damaging	Probably damaging	25.2	0.001	17.44782	High	763866498	0.003
P2RX5	NM_175080.3	c.88G>T	p.G30C	Damaging	Probably damaging	28	3.313	2.65609	Medium	NA	0.000
SBNO2	NM_001100122.2	c.1195G>A	p.E399K	Tolerated	Probably damaging	25.2	3.313	5.7817	Medium	1432406684	0.000
SLC44A2	NM_001145056.2	c.2027A>T	p.N6761	Damaging	Probably damaging	26.9	3.313	2.4366	Medium	768714484	0.004

Genetic variants were identified in the patient using the following criteria: CADD score > 15 and GnomAD frequency < 0.1%. Overview of gene name, transcript variant, protein variant, SIFT function prediction, PolyPhen-2, variant ID, gnomAD frequency, CADD score, MSC, GDI score, GDI prediction, and inferred activity
CADD combined annotation dependent depletion, MSC mutation significance cut-off, SIFT sorting intolerant from tolerant, MSC mutation significance cut-off, gnomAD genome aggregation database, GDI gene damage index