Table 1 Summary of the case reports with an epidermal growth factor receptor exon 18 E709_T710delinsD [4, 9, 10, 14, 15, 18,19,20,21,22]

Wu et al.

Asian

61

F

No

AD

Gefitinib

SD

5.1

22.7

Wu et al.

Asian

65

M

Yes

AD

Gefitinib

PD

0.9

11.1

Kobayashi et al.

Asian

63

M

N/A

AD

Erlotinib**

Afatinib

SD

PR

N/A

N/A

N/AN/A

Ackerman et al.

Non-Asian

88

F

No

AD

Erlotinib

PR

6 (stop)

N/A

Leduc et al.

Non-Asian

N/A

N/A

N/A

N/A

N/A

N/A

3

N/A

Ibrahim et al.

Non-Asian

52

F

No

AD

Afatinib

PR

N/A

N/A

Iwamoto et al.

Asian

56

F

No

AD

Afatinib

PR

7

N/A

An et al.

Asian

71

M

Yes

AD

Afatinib***

PR

11

> 21

Klughammer et al.

Asian

50

F

No

AD

Erlotinib*

PD

38

52

Mehta et al.

Asian

61

M

N/A

AD

Erlotinib*

PR

7

N/A

Sousa et al.

Non-Asian

N/A

N/A

N/A

N/A

Gefitinib

PD

3

24

Sousa et al.

Non-Asian

N/A

N/A

N/A

N/A

Erlotinib*

PD

4

26

Sousa et al.

Non-Asian

N/A

N/A

N/A

N/A

Erlotinib*

PD

3

18

This case

Non-Asian

58

F

No

AD

Afatinib*

PR

> 6

N/A