Fig. 4From: Complete remission in metastatic primary malignant melanoma of the esophagus with nivolumab: a case reportLow-power (a) and high-power (b) magnification of esophageal biopsies showed melanin granules within tumor cells and melanoblasts in the interstitium. Immunohistochemistry was positive for melan A (c). In situ lesions were also observed, suggesting that the esophagus was the primary site (d). Immunohistochemistry for the resected bladder specimen was positive for melan A (e), SOX10 (f), and p53 (g). The MIB-1 proliferation index was 80% (h)Back to article page