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Table 1 Results of skin tests

From: Possible immunoglobulin-E-dependent sugammadex-induced anaphylaxis caused by an epitope other than γ-cyclodextrin: a case report

Drug SPT IDT
Concentration of the stock solution (mg/ml) Results Concentration of the stock solution (mg/ml) Results Wheal (mm) Flare (mm)
Saline 9 9   
Histamine 10 + 0.01 + 15 40
Sugammadex 100 10 + 12 20
Propofol 10 1   
Rocuronium 10 0.1   
Remifentanil 0.05 0.005   
ABPC/SBT 20/10 2/1   
Fentanyl 0.05 0.005   
Flurbiprofen 10 1   
Acetaminophen 10 1   
  1. Saline and histamine were used as negative and positive controls, respectively. Skin prick test (SPT) was started with a 100-fold dilution of stock solution, and a 10-fold dilution and stock solution were inspected. However, none of the drugs except histamine showed a positive result. Subsequently, intradermal tests (IDTs) were performed. After confirming a positive reaction for histamine and a negative reaction for saline, sugammadex showed a positive reaction at a 100-fold dilution of the stock solution, that is, 0.1 mg/ml. Other tested agents did not result in a positive reaction with a 100-fold dilution of the stock solution. ABPC/SBT ampicillin/sulbactam