Possible immunoglobulin-E-dependent sugammadex-induced anaphylaxis caused by an epitope other than γ-cyclodextrin: a case report

Table 1 Results of skin tests

Drug	SPT		IDT
Drug	Concentration of the stock solution (mg/ml)	Results	Concentration of the stock solution (mg/ml)	Results	Wheal (mm)	Flare (mm)
Saline	9	−	9	−
Histamine	10	+	0.01	+	15	40
Sugammadex	100	−	10	+	12	20
Propofol	10	−	1	−
Rocuronium	10	−	0.1	−
Remifentanil	0.05	−	0.005	−
ABPC/SBT	20/10	−	2/1	−
Fentanyl	0.05	−	0.005	−
Flurbiprofen	10	−	1	−
Acetaminophen	10	−	1	−

Saline and histamine were used as negative and positive controls, respectively. Skin prick test (SPT) was started with a 100-fold dilution of stock solution, and a 10-fold dilution and stock solution were inspected. However, none of the drugs except histamine showed a positive result. Subsequently, intradermal tests (IDTs) were performed. After confirming a positive reaction for histamine and a negative reaction for saline, sugammadex showed a positive reaction at a 100-fold dilution of the stock solution, that is, 0.1 mg/ml. Other tested agents did not result in a positive reaction with a 100-fold dilution of the stock solution. ABPC/SBT ampicillin/sulbactam

ISSN: 1752-1947