Table 1 Histopathological and IHC findings of disease from onset to last recurrence
Disease onset | First relapse | Second relapse | Third relapse | |
|---|---|---|---|---|
Skin involvement | Infiltrative erythematous plaque and nodule on left upper shoulder | Ill-defined erythematous nodules on left upper shoulder outside the radiotherapy margin | Two new erythematous nodules on dorsal aspects of left forearm and left leg | Multiple erythematous nodules on upper back, dorsal aspect of right thigh and ventral aspect of left leg |
Other clinical symptoms | Cervical lymphadenopathy | – | – | – |
Histopathology | Lymph node biopsy: not mentioned | Skin biopsy: focal intradermal monomorphous infiltrate of medium-sized blast-like cells without any significant mitotic activity or necrosis | Like the first relapse | Like the first relapse |
Immunohistochemistry | Positive: CD10, CD20, BCL2, TdT, LCA, ki67 | Positive: CD43, CD4, ki67, CD68, CD33, CD56, CD123 | Like the first relapse | Like the first relapse |
Negative: CD3, CD4, CD5, CD16, CD30, CD56, CD79a, BCL6 , PAX-5 | Negative: CD20, CD3, CD30, CD5, CD34, PAX5, CD79a, MPO, Pan CK, Melan A, CD56, TdT, C-kit, CD138, PAX5, CD79a, LCA | – | – |