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Fig. 4 | Journal of Medical Case Reports

Fig. 4

From: Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports

Fig. 4

Results of a PCR-direct sequencing of SDHB intron 4/exon 5 junction. For the daughter, the peripheral blood DNA (germline) showed c.424-2delA in heterozygosity. The tumor tissue DNA showed loss of the wild-type T allele, suggesting LOH. For the father, the primary tumor tissue DNA showed c.424-2delA in heterozygosity. The recurrent tumor tissue DNA showed loss of the wild-type T allele, suggesting LOH. LOH, loss of heterozygosity; PCR, polymerase chain reaction; SDHB, succinate dehydrogenase subunit B

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