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Fig. 3 | Journal of Medical Case Reports

Fig. 3

From: Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports

Fig. 3

The tumors of the daughter (a–c), and of the father (d, e). a Gross section of the PGL. The tumor locates beneath the adrenal gland. b The tumor shows high cellularity with a zellballen pattern. GAPP score is 6 points. c SDHB immunohistochemistry is negative in tumor cells; only endothelial cells are positive. d Tumor cells arranged in zellballen pattern. Intracytoplasmic vacuoles are degenerative changes due to chemotherapy. e SDHB immunohistochemistry is negative in tumor cells, same as in c. b and d: ×200 magnification, and c and e: ×400 magnification. GAPP, grading system for adrenal pheochromocytoma and paraganglioma; PGL, paraganglioma; SDHB, succinate dehydrogenase subunit B

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Journal of Medical Case Reports

ISSN: 1752-1947