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Fig. 2 | Journal of Medical Case Reports

Fig. 2

From: Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature

Fig. 2

a Histologic sections containing extensive coagulative necrosis with angiodestruction and angioinvasion by an atypical lymphocytic infiltrate (hematoxylin and eosin, 4×). b Focally preserved areas showing invasion and destruction of skeletal muscle by an infiltrate of small-to-medium-sized atypical lymphocytes, eosinophils, and histiocytes (hematoxylin and eosin, 20×). c High-power view showing atypical lymphocytes with round to irregular nuclei and condensed chromatin admixed with scattered large cells (hematoxylin and eosin, 40×). d Atypical infiltrate showing strong expression of CD56 (see text for full immunophenotype) (CD56, 40×). e Positive in situ hybridization for EBV-encoded small RNA (EBER) in atypical cells (EBER, 40×). f Subset of cells showing expression of PD-1 (PD-1, 40×)

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