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Table 3 Review of the literature on radiotherapy outcomes of pulmonary ACC

From: Stereotactic body radiotherapy for adenoid cystic carcinoma metastatic to the lung: a case report

Authors

No. of patients

Radiotherapy dose, BED2Gy

Follow-up (months)

Combination therapy

Treatment outcome

Adverse events

Bhandari V [11]

1

54 Gy/30fr., 102.6 Gy

8

No evidence of recurrence

Bronchial stricture grade 1

Das S [13]

1

66 Gy/33 fr., 132 Gy

38

Local recurrence

NR

Haresh KP [14]

1

60 Gy/30 fr., 120 Gy

19

No evidence of recurrence

NR

Kanematsu T [15]

5

50–70 Gy (median 60 Gy),

100–140 Gy (median 120 Gy)

NR

Local recurrence in all five cases (5-year OS, 40%; 10-year OS, 0%)

NR

Kim B [16]

1

66 Gy/33 fr., 132 Gy

20

Paclitaxel, cisplatin, docetaxel, gefitinib

Dead without local recurrence

Radiation pneumonitis grade 1

Lee JH [17]

12

60 Gy/30 fr., 120 Gy

8–167 (median 59)

5 year OS, 54%; 10-year OS, 27%

NR

Liu J [18]

1

65 Gy/35 fr. + endobronchial boost

10 Gy/1 fr., 125.4 Gy + 60 Gy

90

Cisplatin

Local recurrence

Esophagitis grade 3, skin reaction grade 1, and bronchial stricture grade 1

  1. fr. fractions, BED biologically equivalent dose, OS overall survival, LC local control, NR not reported