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Table 3 Review of the literature on radiotherapy outcomes of pulmonary ACC

From: Stereotactic body radiotherapy for adenoid cystic carcinoma metastatic to the lung: a case report

Authors No. of patients Radiotherapy dose, BED2Gy Follow-up (months) Combination therapy Treatment outcome Adverse events
Bhandari V [11] 1 54 Gy/30fr., 102.6 Gy 8 No evidence of recurrence Bronchial stricture grade 1
Das S [13] 1 66 Gy/33 fr., 132 Gy 38 Local recurrence NR
Haresh KP [14] 1 60 Gy/30 fr., 120 Gy 19 No evidence of recurrence NR
Kanematsu T [15] 5 50–70 Gy (median 60 Gy),
100–140 Gy (median 120 Gy)
NR Local recurrence in all five cases (5-year OS, 40%; 10-year OS, 0%) NR
Kim B [16] 1 66 Gy/33 fr., 132 Gy 20 Paclitaxel, cisplatin, docetaxel, gefitinib Dead without local recurrence Radiation pneumonitis grade 1
Lee JH [17] 12 60 Gy/30 fr., 120 Gy 8–167 (median 59) 5 year OS, 54%; 10-year OS, 27% NR
Liu J [18] 1 65 Gy/35 fr. + endobronchial boost
10 Gy/1 fr., 125.4 Gy + 60 Gy
90 Cisplatin Local recurrence Esophagitis grade 3, skin reaction grade 1, and bronchial stricture grade 1
  1. fr. fractions, BED biologically equivalent dose, OS overall survival, LC local control, NR not reported