Fig. 3

Histomorphology and immunohistochemistry of the pancreatic body/tail lesions. a Microscopic overview of ccRCC metastasis (bottom left) and PDAC (upper right) in immediate juxtaposition to one another (hematoxylin and eosin [H&E], 20×). b Higher magnification of ccRCC metastasis displaying its typical histomorphology with a solid growth of tumor cells with clear cytoplasm (H&E, 80×). c Immunohistochemistry for vimentin showing membranous positivity, confirming ccRCC metastasis (100×). d ccRCC metastasis also verified by nuclear positivity for Pax-8 in immunohistochemistry (200×). e Higher magnification of PDAC, containing irregular tubuli (bottom left), but also solid areas with vacuolized eosinophilic cytoplasm and highly pleomorphic nuclei, accounting for regressive changes after neoadjuvant therapy (upper right) (H&E, 80×). f, g PDAC tumor cell complexes showing characteristic positivity for Ca19-9 (f) and CK7 (g) on immunohistochemistry (80×)